Figure 3

Analyses of biological pathways associated with SJIA ESR, SJIA JC and POLY ESR. Comparative analyses determine pathways that are significantly different in their association with SJIA ESR vs JC (top panels) or that differentiate SJIA/ESR and POLY/ESR cohorts (bottom panels). (A) Pearson correlation analysis between SJIA ESR and JC related pathways identified by Ingenuity Analysis. (B) Simulation analyses to determine the threshold for significantly differentiating pathways between ESR and JC in SJIA. Densities of the absolute differences between SJIA ESR- and JC-related pathways, for the original and the simulation data sets (20%, 50% and 80%) are shown. See Methods for more details. (C) Pearson correlation between SJIA and POLY ESR-related pathways identified by Ingenuity Analysis. (D) Simulation analysis to determine the threshold for significantly differentiating pathways between SJIA and POLY ESR, performed as in (B).