IPA Canonical Pathways | -Logarithm (P-value) | Difference (ESR-JC) | Gene expression with higher ESR/JC* | |
---|---|---|---|---|
 | SJIA ESR | SJIA JC |  |  |
Glucocorticoid receptor signaling | 5.68 | 3.07 | 2.61 | Higher (both) |
PI3K/AKT signaling | 1.27 | 3.73 | -2.45 | Higher (both) |
Role of PKR in interferon induction and antiviral response | 4.43 | 4.43 | 0 | Higher (both) |
Altered T cell and B cell signaling in rheumatoid arthritis | 3.91 | 3.91 | 0 | Higher (both) |
T helper cell differentiation | 3.74 | 3.74 | 0 | Lower (both) |
iCOS-iCOSL signaling in T helper cells | 3.73 | 3.73 | 0 | Lower (both) |
CD40 signaling | 3.73 | 3.73 | 0 | Lower (both) |
MIF regulation of innate immunity | 3.70 | 3.70 | 0 | Higher (both) |
LPS-stimulated MAPK signaling | 3.42 | 3.42 | 0 | Higher (both) |
CD27 signaling in lymphocytes | 3.18 | 3.18 | 0 | Higher (both) |
MIF-mediated glucocorticoid regulation | 3.02 | 3.02 | 0 | Higher (both) |
Role of cytokines in mediating communication between immune cells | 3.01 | 3.01 | 0 | Higher (both) |
TREM1 signaling | 2.91 | 2.91 | 0 | Higher (both) |
Crosstalk between dendritic cells and natural killer cells | 2.81 | 2.81 | 0 | Lower (both) |
Docosahexaenoic acid (DHA) signaling | 2.76 | 2.76 | 0 | Higher (both) |
Regulation of IL-2 expression in activated and anergic T lymphocytes | 2.39 | 2.39 | 0 | Higher (both) |
Toll-like receptor signaling | 2.37 | 2.37 | 0 | Lower (both) |
fMLP signaling in neutrophils | 2.33 | 2.33 | 0 | Higher (both) |
TNFR1 signaling | 2.22 | 2.22 | 0 | Higher (both) |
RANK signaling in osteoclasts | 2.16 | 2.16 | 0 | Lower (both) |
4-1BB signaling in T lymphocytes | 2.12 | 2.12 | 0 | Higher (both) |
CD28 signaling in T helper cells | 2.11 | 2.11 | 0 | Lower (both) |
Communication between innate and adaptive immune cells | 2.06 | 2.06 | 0 | Higher (both) |
T cell receptor signaling | 2.03 | 2.03 | 0 | Lower (both) |
ILK signaling | 2.01 | 2.01 | 0 | Higher (both) |