Table 6 Biologic pathways that distinguish or are shared between SJIA ESR and POLY ESR
IPA Canonical Pathways | -Logarithm (P-value) | Difference (SJIA-POLY) | Gene expression with higher SJIA ESR/ POLY ESR | |
|---|---|---|---|---|
| Â | SJIA ESR | POLY ESR | Â | Â |
IL-10 signaling | 8.56 | 4.22 | 4.34 | Higher (both) |
Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis | 6.80 | 1.14 | 5.65 | Higher (both) |
Role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis | 5.84 | 0.82 | 5.01 | Higher (both) |
Glucocorticoid receptor signaling | 5.68 | 1.34 | 4.34 | Higher (both) |
B cell receptor signaling | 5.60 | 2.07 | 3.53 | Higher (both) |
Role of PKR in interferon induction and antiviral response | 4.43 | 0.86 | 3.56 | Higher (both) |
Systemic lupus Erythematosus signaling | 4.08 | 0.46 | 3.62 | Higher (both) |
altered T cell and B cell signaling in rheumatoid arthritis | 3.91 | 1.34 | 2.57 | Higher (both) |
A proliferation-inducing ligand mediated signaling | 3.80 | 0.95 | 2.86 | Lower (both) |
IL-15 signaling | 3.76 | 0.76 | 3.01 | Lower (both) |
T helper cell differentiation | 3.74 | 0.00 | 3.74 | Lower (both) |
iCOS-iCOSL signaling in T helper cells | 3.73 | 0.51 | 3.22 | Lower (both) |
CD40 signaling | 3.73 | 0.75 | 2.98 | Lower (both) |
B cell activating factor signaling | 3.70 | 0.93 | 2.77 | Lower (both) |
Dendritic cell maturation | 3.65 | 0.94 | 2.71 | Higher (both) |
IL-12 signaling and production in macrophages | 3.08 | 0.52 | 2.55 | Lower (both) |
p38 MAPK signaling | 3.08 | 0.52 | 2.55 | Higher (both) |
PPAR alpha/RXR alpha activation | 2.96 | 0.42 | 2.55 | Higher (both) |