Notch signaling in pediatric soft tissue sarcomas

Table 2 Completed clinical trials with γ-secretase inhibitors in pediatric/young adult oncologic patients (clinicaltrials.gov).

Compound	ClinicalTrials Gov Identifier	Clinical studies	Cancer type	Patients'age
MK0752	NCT00106145	Phase I study	Breast and advanced solid tumors	18 Years and older
MK0752	NCT00100152	Phase I study	T-ALL	12 Months and older^a
RO4929097	NCT01192763	Phase I study	Pancreatic cancer	18 Years and older
RO4929097	NCT01208441	Phase I study	Breast cancer	18 Years and older
RO4929097	NCT01269411	Phase I study	Brain and Central Nervous System Tumors	18 Years and older
RO4929097	NCT01216787	Phase II study	Melanoma (Skin)	18 Years and older
RO4929097	NCT01217411	Phase I study	Breast Cancer	18 Years and older
RO4929097	NCT01151449	Phase II study	Breast Cancer	18 Years and older
RO4929097 with or without Bevacizumab	NCT01270438	Phase II study	Metastatic Colorectal Cancer	18 Years and older
RO4929097	NCT01236586	Phase I/II study	Brain and Central Nervous System Tumors, T-ALL	1 Year to 21 Years^a
RO4929097	NCT01088763	Phase I/II study	Leukemia	1 Year to 21 Years^a

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