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Table 2 Multiplex proteomics analysis of the coronary artery disease (CAD) and normal (NOR) patient groups

From: Serum protein profiles predict coronary artery disease in symptomatic patients referred for coronary angiography

  Average NOR SD N Average CAD SD N Pvalue
OPN 16.4 ng 15.3 ng 149 40.6 ng 38.1 ng 206 < 0.001
VCAM 980.7 ng 493.8 ng 149 1,266.5 ng 492.5 ng 206 < 0.001
APO-A1 293.7 μg 257.4 μg 91 152.5 μg 134.5 μg 135 < 0.001
IL-6 0.6 ng 1.1 ng 101 1.5 ng 1.8 pg 135 < 0.001
MPO 538.2 ng 333.9 ng 147 731.1 ng 532.5 ng 206 < 0.001
IL-1β 56.9 pg 124.0 pg 149 109.0 pg 164.0 pg 206 < 0.005
NT-pBNP 33.3 pg 59.4 pg 91 103.2 pg 204.5 pg 135 < 0.005
Fibrinogen 4.8 μg 5.8 μg 149 25.6 μg 81.6 μg 206 < 0.005
APO-B100 273.2 μg 80.6 μg 149 300.6 μg 93.0 μg 206 < 0.005
Resistin 89.5 ng 63.0 ng 149 110.7 ng 77.0 ng 206 < 0.005
CRP 1.1 μg 2.4 μg 149 3.3 μg 9.7 μg 201 < 0.005
IL-10 3.3 pg 3.7 pg 91 7.6 pg 18.4 pg 135 < 0.005
MMP1 4.7 ng 2.3 ng 91 5.3 ng 2.4 ng 135 0.015 (NS)
Leptin 13.6 ng 18.0 ng 100 10.0 ng 16.0 ng 133 0.027 (NS)
ACRP30 5.9 μg 3.9 μg 149 5.2 μg 4.0 μg 206 0.027 (NS)
MMP7 4.8 ng 3.3 ng 149 5.2 ng 2.4 ng 206 0.045 (NS)
TNFα 22.7 pg 77.1 pg 91 14.7 pg 19.3 pg 135 0.059 (NS)
IFNγ 3.6 pg 10.8 pg 149 4.7 pg 10.0 pg 206 0.069 (NS)
L-selectin 1.1 μg 0.2 μg 91 1.1 μg 0.3 μg 135 0.074 (NS)
MCP1 3.1 ng 3.7 ng 91 3.4 ng 3.4 ng 135 0.114 (NS)
PECAM-1 44.0 ng 32.1 ng 57 45.8 ng 27.2 ng 79 0.116 (NS)
TIMP1 321.3 ng 101.1 ng 91 327.2 ng 86.1 ng 135 0.116 (NS)
E-selectin 33.2 ng 19.2 ng 91 34.1 ng 16.6 ng 135 0.123 (NS)
TM 1.4 ng 0.8 ng 91 1.4 ng 0.4 ng 135 0.128 (NS)
  1. Protein concentrations are reported in pg, ng or μg per ml of serum with adjusted P values for false discovery rate (FDR) at a cut-off for statistical significance between the NOR and CAD groups = 0.01. NS indicates that no significant statistical differences were detected with the calculated P values provided in parenthesis.
  2. ACRP-30 = adiponectin; APO-A1 = apolipoprotein A1; APO-B100 = apolipoprotein B100; CRP = C-reactive protein; E-selectin = endothelial leukocyte adhesion molecule 1; IFNγ = interferon γ; IL = interleukin; L-selectin = leukocyte selectin; MCP-1 = monocyte chemoattractant protein 1; MMP matrix metalloproteinase; MPO = myeloperoxidase; NT-pBNP = N-terminal fragment protein precursor brain natriuretic peptide; OPN = osteopontin; PECAM-1 = platelet endothelial cell adhesion molecule 1; TIMP-1 = tissue inhibitor of metalloproteinase 1; TM = thrombomodulin; TNFα = tumor necrosis factor α; VCAM-1 = vascular cell adhesion molecule 1.