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Table 2 Examples of immune effects by histamine receptor-2 antagonists

From: Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis

Agent

Cell/whole animal

Response

Reference

Cimetidine

Guinea pigs

Increases activity of delayed type hypersensitivity and experimental autoimmune encephalomyelitis incidence

[25]

Cimetidine

Mouse T cells

Inhibits induction of T suppressor cells

[45]

Cimetidine

Mouse splenocytes

Increases antibody production, and proliferation of mitogen-activated splenocytes in response to tetanus toxoid

[51]

Cimetidine

Mouse T cells

Inhibits regulatory T cell-like activity

[49]

Cimetidine

Human T cells

Reduces suppressor T cell response

[46]

Cimetidine

Human lymphocytes

Increases the mitogen-activated T cell response

[42, 43]

Cimetidine

Human DCs

Increases the capacity of antigen presentation by DCs from immunosuppressed cancer patients

[75]

Ranitidine

Human T cells

Increases CD4+ T cells and mitogen-stimulated IFN-γ production from patients with head injury

[52]

Ranitidine

Human monocytes, neutrophils, natural killer cells, delayed type hypersensitivity

Reverses surgery-induced immune suppression

[54, 55]

  1. DC: dendritic cell; IFN-γ: interferon gamma.