Marker | Outcome | Cut-off | Sensitivity (95% CI) | Specificity (95% CI) |
---|---|---|---|---|
CRP (7 studies, 731 episodes) | Documented infection | > 50 mg/dl | 0.65 (0.41 to 0.84) | 0.73 (0.63 to 0.82) |
PCT (3 studies, 216 episodes) | Documented infection | > 0.2 mg/ml | 0.96 (0.05 to 0.99) | 0.85 (0.53 to 0.97) |
IL6 (3 studies, 457 episodes) | Documented infection | > 235 pg/ml | 0.68 (0.15 to 0.96) | 0.94 (0.84 to 0.98) |
IL6 (2 studies, 166 episodes) | Gram negative bacteremia | > 1,000 pg/ml | 0.78 (0.57 to 0.91) | 0.96 (0.92 to 0.99) |