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Table 3 Bivariate estimates of diagnostic precision of various biomarkers and outcomes

From: Systematic review and meta-analysis of the value of initial biomarkers in predicting adverse outcome in febrile neutropenic episodes in children and young people with cancer

Marker

Outcome

Cut-off

Sensitivity (95% CI)

Specificity (95% CI)

CRP

(7 studies, 731 episodes)

Documented infection

> 50 mg/dl

0.65 (0.41 to 0.84)

0.73 (0.63 to 0.82)

PCT

(3 studies, 216 episodes)

Documented infection

> 0.2 mg/ml

0.96 (0.05 to 0.99)

0.85 (0.53 to 0.97)

IL6

(3 studies, 457 episodes)

Documented infection

> 235 pg/ml

0.68 (0.15 to 0.96)

0.94 (0.84 to 0.98)

IL6

(2 studies, 166 episodes)

Gram negative bacteremia

> 1,000 pg/ml

0.78 (0.57 to 0.91)

0.96 (0.92 to 0.99)