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Table 6 Summary of clinical studies with bioresorbable membranes for reconstruction of segmental mandibular defects

From: The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence

Author/Year [ref]

Study design

No. of pts

Mandibular reconstruction

Defect size

Etiology

Type of membrane

Graft

Type of fixation

Outcome

Kinoshita

2004 [33]

case series (1995 to 2001)

62

Mandibulectomy (segmental defect and hemimandibulectomy)

_

malignant (22) and benign (30) tumors, cysts (5), osteomyelitis (2), alveolar atrophy (1) trauma (2)

Absorbable

PLLA mesh

Autologous cancellous bone graft

+ bone marrow

+/- stainless steel wires

At six months post-operation:

Excellent (markedly effective) 56.5%

Good (effective) 27.4%

Poor (not effective) 16.1%

X-ray of the regenerated bone: 0 to 10% bone resorption in 31 cases

10% to 20% in six cases

20% to 30% in one case

Kinoshita

2000 [133]

case series (1995 to 1998)

41

Segmental defect or large partial defects mandibulectomy

_

malignant (19) and benign (22) tumors

  

-

Excellent: 19/41 (46.3%)

Good 13/41 (31.7%)

Poor 9/41 (22.2%) (local infection)

86.5% Success rate

Five years: no problems from PLLA and good osseointegration

Kinoshita

1996 [57]

case series

2

Segmental defect or large partial defect

right to left molar areas

tumor

  

stainless steel wires

At three months: full bone regeneration