Skip to main content

Table 7 Summary of clinical studies with bioabsorbable membranes for reconstruction of long bone defects

From: The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence

Author/Year [ref]

Study design

No of patients

Site

Size of defect

Etiology

Type of membrane

Graft

Type of fixation

Evaluation

Outcome

Meining 2010 [13]

case series

Six

Tibia (five)

Femur (one)

≥ CSD

Trauma

poly(L/DL-lactide)

80/20% membranes with 50 to 70

μm pore size

RIA, ICBG

IMN, plating

X-rays

Healing

one case: re-grafting after 15 months

Ip

2004 [134]

case series

Ten

Not reported

≤ 6 cm

Benign tumor, Osteomyelitis and trauma

 

polymeric scaffolds (sponges, 450 to 700 μm pore size) impregnated with bone marrow

Not reported

X-rays

Presence of bone regeneration and satisfactory function

  1. CSD, critical size defect; ICBG, iliac crest bone graft; IMN, intermedullary nailing; RIA, Reamer/Irrigator/Aspirator.