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Table 3 Tests of fixed effects in MMRM for measures of psychopathology and functioning.

From: Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial

Effect

F test

df

Pvalue

 

F test

df

Pvalue

Symptoms

       

   YMRS †

   

MADRS Total Score†

   

Group

2.04

1, 113.4

.156

Group

0.26

1, 121.7

.610

Time

1.45

6, 285.4

.197

Time

3.15

6, 240.6

.005

Group by time

0.99

6, 285.4

.432

Group by time

0.44

6, 240.6

.855

   BDRS †

       

Group

0.27

1, 124.8

.604

    

Time

3.83

6, 245.2

.001

    

Group by time

0.49

6, 245.2

.813

    

   CGI-BP Severity Depression †

   

CGI-BP Improvement Depression †

  

Group

0.03

1, 126.0

.863

Group

0.14

1, 123.6

.709

Time

1.03

6, 197.4

.405

Time

2.43

6, 341.8

.026

Group by time

0.60

6, 197.4

.731

Group by time

0.54

6, 341.8

.777

   CGI-BP Severity Mania †

   

CGI-BP Improvement Mania†

   

Group

0.01

1, 116.0

.935

Group

0.05

1, 124.3

.822

Time

0.38

6, 247.2

.893

Time

1.99

6, 303.2

.066

Group by time

0.75

6, 247.2

.614

Group by time

1.32

6, 303.2

.248

   CGI-BP Severity Overall †

   

CGI-BP Improvement Overall†

   

Group

0.15

1, 122.7

.704

Group

0.05

1, 125.3

.828

Time

1.31

6, 201.0

.255

Time

3.10

6, 335.6

.006

Group by time

0.47

6, 201.0

.829

Group by time

0.38

6, 335.6

.893

Functioning

       

   GAF

   

SOFAS

   

Group

1.60

1, 121.9

.209

Group

0.46

1, 121.7

.500

Time

2.90

6, 252.9

.010

Time

4.43

6, 311.8

<.001

Group by time

0.75

6, 252.9

.609

Group by time

0.95

6, 311.8

.460

   LIFE-RIFT

   

SLICE-LIFE

   

Group

0.95

1, 121.4

.332

Group

0.12

1, 119.8

.732

Time

1.09

6, 242.0

.370

Time

0.86

6, 275.5

.525

Group by time

0.52

6, 242.0

.794

Group by time

0.62

6, 275.5

.714

   QLESQ

       

Group

0.53

1, 123.2

.466

    

Time

1.99

6, 265.4

.067

    

Group by time

0.16

6, 265.4

.987

    
  1. YMRS, Young Mania Rating Scale; MADRS, Montgomery-Asberg Depression Rating Scale; BDRS, Bipolar Depression Rating Scale; CGI-BP Clinical Global Impressions - Bipolar Disorder; GAF, Global Assessment of Functioning; SOFAS, Social and Occupational Assessment Scale; LIFE-RIFT, Range of Impaired Functioning Tool; SLICE-LIFE, Streamed Longitudinal Interval Clinical Evaluation of the Longitudinal Interview Follow-Up Evaluation; Q-LES-Q, Quality of Life Enjoyment and Satisfaction Questionnaire. † Inferential statistics based on logarithmic transformed data (plus constant) because of extreme positive skewness.