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Table 3 Prevalence of high risk conditions among RV hospitalizations and their association with disease outcome and healthcare utilization

From: Targeted rotavirus vaccination of high-risk infants; a low cost and highly cost-effective alternative to universal vaccination

 

Prevalence

P-valueb

RRb

 

 Observational study

Weighted estimates national RV hospitalizations (95% CI)

General infant populationa

  

High Risk Conditions

%

N

%

N

%

N

  

GA < 36 weeks

8.9

83

6.8 (5.1; 8.5)

347 ( 243; 451)

4.3

7617

0.005

1.7 (1.2; 2.8)

LBW

11.1

104

8.8 (6.6; 11.1)

462 (309; 615)

6.0

10545

0.014

1.6 (1.1; 2.3)

Congenital pathology

12.4

116

6.2 (4.9; 7.4)

309 (244; 374)

1.5

2719

<0.0001

4.4 (3.4; 5.4)

 

Healthy (N = 657)

 

High risk conditions

   

GA <36 weeks (N = 83)

LBW (N = 104)

Congenital pathology (N = 116)

Outcome and healthcare utilization

N (%)

 

N (%)

RR (95% CI)

N (%)

RR (95% CI)

N (%)

RR (95% CI)

ICU admission

4 (0.6%)

 

4 (4.8%)

7.9 (2.0; 31.1)

3 (2.9%)

4.7 (1.1; 20.9)

3 (2.6%)

4.2 (1.0; 18.7)

RV related death (number,%)

0

 

0

 

0

 

2 (1.7%)

NA

    

Mean difference (95% CI)

 

Mean difference (95% CI)

 

Mean difference (95% CI)

LOS (mean, SD)

3.6 (2.1)

 

5.2 (4.7)

+1.6 (0.1; 3.0)

5.1 (4.5)

+1.5 (0.3; 2.7)

6.6 (4.2)

+3.0 (1.9; 4.1)

Healthcare costs (mean, SD)

2,203 (2,113)

 

3,001 (3,407)

+798 (28; 1,568)

2,851 (3,206)

+648 (−2; 1,297)

3,737 (3,500)

+1,533 (867; 2,199)

  1. aDutch birth cohort alive after one month, 2005-200838; bComparing weighted RV hospitalizations prevalence to population prevalence.
  2. GA: gestational age; LBW: low birth weight; LOS, length of stay; RR, relative risk; RV, rotavirus; SD: standard deviation.
  3. The figures in bold indicate the results of calculations form other columns in the table and represent the main findings.