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Table 2 Strength of evidence for biological factors supporting merging in some way schizophrenia, schizoaffective and bipolar I disorder

From: Informing DSM-5: biological boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia

Biological factor

Strength of evidence

Genetics—family studies

Strongest

Genetics—twin studies

Moderate

Genetics—candidate gene/GWAS

Moderate

Brain—morphology

Moderate

Pharmacotherapeutics—lithium, divalproex, lamotrigine, antipsychotics

Weak

  1. GWAS, genome wide association studies.
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BMC Medicine

ISSN: 1741-7015

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