Reference | Nr of melancholic depression | Nr of atypical depression | Nr of controls | Summary of findings |
---|---|---|---|---|
Metabolic dysregulation | ||||
Lamers et al. 2010 [115] | 379 | 201 | - | AD more MetS than MD |
Seppala et al. 2012 [53] | 293 | 1391 | 2,388 | AD more MetS than C, no association with MD |
Immuno-inflammatory dysregulation | ||||
Anisman et al. 1999 [123] | 17 | 31 | 27 | No difference in IL-1b + IL-2 |
Kaestner et al. 2005 [124] | 21 | 161 | 37 | AD higher IL-1b + IL-1RA than C + MD |
Huang et al. 2007 [125] | 25 | 171 | 40 | MD higher IL-1b than AD no difference in IL-10 and TNF-α |
Yoon et al. 2012 [126] | 70 | 35 | - | AD higher IL-2 and lower IL-4 than MD no differences in IL-6 + TNF-α |
Lamers et al. 2012 [127] | 111 | 122 | 543 | AD higher IL-6 + CRP + TNF-α than MD + C |
Karlovic et al. 2012 [128] | 32 | 23 | 18 | MD + AD higher IL-6 + CRP than C no difference in TNF-α |
HPA-axis dysregulation | ||||
Nelson et al. 1997 [110] | 662 | 6171 | - | MD more DST non-suppression than AD |
Anisman et al. 1999 [123] | 17 | 31 | 27 | AD lower cortisol than C |
Wong et al. 2000 [129] | 10 | - | 14 | MD higher cortisol than C |
Kaestner et al. 2005 [124] | 21 | 161 | 37 | MD higher cortisol than AD + C |
Lamers et al. 2012 [127] | 66 | 82 | 393 | MD higher cortisol than AD + C |
Karlovic et al. 2012 [128] | 32 | 23 | 18 | MD higher cortisol than AD + C |