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Table 1 Differences in clinical efficacy of antihypertensive drugs in ancestrygroups

From: Why do hypertensive patients of African ancestry respond better to calciumblockers and diuretics than to ACE inhibitors and β-adrenergic blockers? Asystematic review

 

Systolic/diastolic blood pressure reduction*

 

Drug category

European ancestry

African ancestry

Difference

Calcium blockers

15.3/12.6

16.9/13.3

2.4/0.6

(14.7, 15.9)/(12.3, 12.9)

(16.0, 17.7)/(12.9, 13.8)

(3.4, 1.3)/(1.2, 0.0)

Diuretics

11.5/9.1

15.0/10.7

3.5/1.5

(9.5, 13.4)/(8.1, 10.1)

(13.1, 17.0)/(9.5, 11.9)

(6.4, 0.5)/(3.1, −0.1)

ACE-i

12.8/11.4

8.5/8.0

−4.6/−3.0

(11.7, 13.9)/(10.8, 12.0)

(7.0, 9.9)/(7.1, 8.9)

(−2.7, −6.5)/(−1.9, −4.1)

β-Blockers

11.7/11.3

5.9/9.5

−6.0/−2.9

(10.2, 13.3)/(10.5, 12.1)

(4.2, 7.6)/(8.5, 10.4)

(−3.6, −8.3)/(−1.6,−4.2)

  1. Legend: Data depicted are pooled estimates (95% confidence intervals)from systematic reviews [3, 7]. ACE-i, angiotensin converting enzyme inhibitors. *Mean bloodpressure reduction (mm Hg). The depicted difference isthe weighted pooled difference in response between ancestry groups, withpositive values indicating a greater response in patients of Africanancestry and negative values indicating a greater response in patientsof European ancestry.