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Table 1 Examples of pharmacogenomics tests regarding responses or toxicities to drug treatments

From: Personalizing health care: feasibility and future implications

Disease area

Host genotype

Treatment

References

Optimizing drug efficacy

   

Chronic hepatitis C

IL28B

Pegylated interferon alpha, Ribavirin

[127–129]

Breast cancer, other tumors

 

Anthracyclines, poly(adenosine diphosphate-ribose) polymerase inhibition

[117, 130–132]

Preventing drug toxicities

   

HIV type 1

(HLA)-B*5701

Abacavir

[1, 4, 35, 106, 133]

Rheumatic and inflammatory bowel disorders

Thiopurine methyl transferase genotypes

Azathioprine

[19–21, 58, 59, 133–135]

HLA-B*58:01

Allopurinol

Gastrointestinal cancers

Dehydropyrimidine dehydrogenase deficiency

5-fluorouracil

[136]

UGT1A1 polymorphism

Irinotecan

[137]