Table 4 Models of diagnosis: a overall cost b and numbers of investigations for screening 1,000 adult men or women in the community for CD
Screen | Sex | Model | |||||||
|---|---|---|---|---|---|---|---|---|---|
A | B | C | D | E | F | G | H | ||
TG2 IgAc | F | 1,000 | 1,000 | 1,000 | 1,000 | – | – | – | – |
M | 1,000 | 1,000 | 1,000 | 1,000 | – | – | – | – | |
Composite TG2/DGP IgA/IgGc | F | – | – | – | – | – | 1,000 | 1,000 | 1,000 |
M | – | – | – | – | – | 1,000 | 1,000 | 1,000 | |
HLA-DQd | F | – | – | – | – | 1,000 | – | – | – |
M | – | – | – | – | 1,000 | – | – | – | |
Confirmatory test if initial test is ‘positive’ | |||||||||
 TG2 IgAc | F | – | – | – | – | 560 | – | – | – |
M | – | – | – | – | 557 | – | – | – | |
 EMAc | F | – | – | 45 | 3 | 19 | – | – | – |
M | – | – | 69 | 2 | 37 | – | – | – | |
 TG2 IgA and DGP-G, DGP-Ae | F | – | – | – | – | – | – | – | 52 |
M | – | – | – | – | – | – | – | 79 | |
 HLA-DQd | F | – | 45 | 45 | 3 | – | – | 52 | 52 |
M | – | 69 | 69 | 2 | – | – | 79 | 79 | |
Biopsy if initial and/or confirmatory tests are positivef | |||||||||
 Biopsy | F | 45 | 32 | 32 | 42 | 18 | 52 | 38 | 28 |
M | 69 | 45 | 45 | 67 | 16 | 79 | 48 | 24 | |
 Cases diagnosedg | F | 13 | 13 | 13 | 13 | 13 | 19 | 19 | 19 |
M | 13 | 13 | 13 | 13 | 13 | 12 | 12 | 12 | |
 Total cost for investigations, A$ | F | 63,150 | 57,484 | 58,605 | 61,034 | 149,367 | 69,100 | 63,422 | 57,010 |
M | 83,550 | 71,406 | 73,124 | 82,139 | 148,041 | 92,050 | 75,152 | 57,924 | |
 Cost per case screened, A$ | F | 63 | 57 | 59 | 61 | 149 | 69 | 63 | 57 |
M | 84 | 71 | 73 | 82 | 148 | 92 | 75 | 58 | |
 Cost per case diagnosed, A$ | F | 4,858 | 4,422 | 4,508 | 4,695 | 11,490 | 3,637 | 3,338 | 3,001 |
| Â | M | 6,427 | 5,493 | 5,625 | 6,318 | 11,388 | 7,671 | 6,263 | 4,827 |