From: How do autoimmune diseases cluster in families? A systematic review and meta-analysis
Disease in probands | Author and year | Country | Study type | Total number of probands | Affected FDRs in probands | Total number FDRs | Total controls | Affected FDRs in controls | Total FDRs in controls | Oxford 2011 level of evidence | Observations |
---|---|---|---|---|---|---|---|---|---|---|---|
AITD | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Boelaert 2010 [33] | UK | Cross sectional | 3286 | 845 | 6572 |  |  |  | 3 |  |
 | Hemminki 2009 [34] | Sweden | Cohort | 15,743 | 1,135 | 2,412 |  |  |  | 3 |  |
 | Criswell 2005 [35] | USA | Cross sectional | 43 | 21 | 232 |  |  |  | 3 |  |
T1D | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Criswell 2005 [35] | USA | Cross sectional | 10 | 6 | 232 |  |  |  | 3 |  |
 | Bottazzo 1978 [36] | UK | Cross sectional | 116 | 4 | 257 |  |  |  | 3 |  |
 | Anaya 2006 [37] | Colombia | C&C | 98 | 18 | 312 | 113 | 9 | 362 | 3 |  |
 | Wagner 2011 [38] | Spain | Cross sectional | 12,973 | 97 | 1,279 |  |  |  | 3 | Non diabetic siblings |
 |  |  |  | 12,973 | 1,001 | 6,262 |  |  |  |  | Diabetic siblings |
 | Hemminki 2009 [39] | Sweden | Cohort | 21,168 | 1,913 | 5,195 |  |  |  | 3 |  |
 | Samuelsson 2004 [40] | Lithuania/Sweden | C&C | 803 | 114 |  | 1,944 | 229 |  | 3 | N = for controls and for FDRs is not specified |
 | Lebenthal 2011a [41] | Israel | Cross sectional | 121 | 57 |  |  |  |  | 3 | Familial T1D patients |
 |  |  |  | 226 | 43 |  |  |  |  |  | Sporadic T1D patients. |
 |  |  |  |  |  |  |  |  |  |  | Numbers of FDRs are not given |
SLE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Alarcón Segovia 2005 [42] | Latin america | Cross sectional | 1,177 | 50 |  |  |  |  | 3 | Total number of FDRs is not specified |
 | Priori 2003 [43] | Italy | C&C | 154 | 39 | 759 | 140 | 12 | 776 | 3 |  |
 | Corporaal 2002 [44] | The Netherlands | Cross sectional | 135 | 42 | 693 |  |  |  | 3 |  |
 | Criswell 2005 [35] | USA | Cross sectional | 65 | 47 | 232 |  |  |  | 3 |  |
RA | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Criswell 2005 [35] | USA | Cross sectional | 46 | 31 | 232 |  |  |  | 3 |  |
 | Lin 1998 [45] | USA | C&C | 29 | 25 | 218 | 14 | 4 | 98 | 3 |  |
 | Thomas 1983 [46] | UK | C&C | 295 | 19 | 2,081 | 307 | 8 | 2,299 | 3 |  |
 | Hemminki 2009 [47] | Sweden | Cohort | 47,361 | 1,919 | 4,677 |  |  |  | 3 |  |
 | Jawaheer 2004 [48] | USA | C&C | 1,097 | 10 |  |  | 83 |  | 3 | N = for controls and for total FDRs are not specified |
MS | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Barcellos 2006 [32] | USA | Cross sectional | 176 | 119 | 1,107 |  |  |  | 3 |  |
 | Criswell 2005 [35] | USA | Cross sectional | 82 | 64 | 232 |  |  |  | 3 |  |
 | Broadley 2000 [49] | UK | C&C | 571 | 879 | 3,949 | 375 | 879 | 3949 | 3 | Individual numbers of FDRs of cases and controls are not given |
 | Deretzi 2010 [50] | Greece | C&C | 891 | 410 | 3,112 | 355 | 96 | 1580 | 3 |  |
 | Heinzlef 2000 [51] | France | Cross sectional | 357 | 33 | 1,971 |  |  |  | 4 |  |
 | Henderson 2000 [52] | Australia | C&C | 157 | 53 | 722 | 222 | 1582 | 1138 | 3 |  |
 | Marrosu 2002 [53] | Italy | Cohort | 1,090 | 53 | 5,480 |  |  |  | 3 |  |
 | Ramagopalan 2007 [54] | Canada | Cross sectional | 5,031 | 786 | 30,259 |  |  |  | 3 |  |
 | Nielsen 2008 [55] | Denmark | Cohort | 8,205 | 260 | 20,800 |  |  |  | 3 |  |
 | Laroni 2005 [56] | Italy | C&C | 245 | 21 | 984 | 245 | 13 | 1,002 | 4 |  |
SSc | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Arora Singh 2010 [57] | USA |  | 1,071 | 184 | 4,612 |  |  |  | 3 |  |
 | Hudson 2008 [58] | Canada | Cross sectional | 719 | 260 | 715 |  |  |  | 3 |  |
 | Koumakis 2012 [59] | France | C&C | 373 | 245 | 823 | 250 | 70 | 318 | 3 |  |
 | Frech 2010 [60] | USA | Nested C&C | 1,037 | 95 | 4,629 | 10,370 | 417 | 49,312 | 3 | Total number of FDRs, from controls, is not specified but ten controls were selected per proband |
SS | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Reveille 1984 [61] | USA | Cross sectional | 98 |  |  |  |  |  | 3 | Total number of FDRs and affected FDRs are not specified |
 | Anaya 2006 [62] | Colombia | C&C | 101 | 56 | 876 | 124 | 33 | 857 | 3 |  |
UC | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Hemminki 2010 [63] | Sweden | Cohort | 25,846 | 2,528 | 5,121 |  |  |  | 3 |  |
CrD | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Hemminki 2010 [63] | Sweden | Cohort | 18,885 | 2,169 | 4,306 |  |  |  | 3 |  |
IBD | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Criswell 2005 [35] | USA | Cross sectional | 7 | 8 | 232 |  |  |  | 3 |  |
VIT | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Alkhateeb 2003 [64] | USA/UK | Cross sectional | 2,624 | 660 | 8,034 |  |  |  | 3 |  |
 | Laberge 2005 [65] | USA | Cross sectional | 133 | 98 | 331 |  |  |  | 3 |  |
 | Zhang 2009 [66] | China | Cross sectional | 5,601 | 340 | 18,705 |  |  |  | 3 |  |
JRA | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Prahalad 2002 [67] | USA | C&C | 110 | 72 | 446 | 45 | 29 | 181 | 3 |  |
 | Huang 2004 [68] | Taiwan | Cross sectional | 110 | 5 |  |  |  |  | 3 | Total number of FDRs is not specified |
JSLE | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Huang 2004 [68] | Taiwan | Cross sectional | 91 | 6 |  |  |  |  | 3 | Total number of FDRs is not specified |
 | Walters 2012 [69] | USA | Cross sectional | 69 | 23 |  |  |  |  | 3 | Total number of FDRs is not specified |
IIM | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Ginn 1998 [70] | USA | C&C | 21 | 33 | 151 | 21 | 7 | 143 | 3 |  |
 | Niewold 2011 [71] | USA | Cross sectional | 304 | 30 | 1,224 |  |  |  | 3 |  |
CD | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Petaros 2002 [72] | Italy | C&C | 125 | 18 | 373 | 125 | 4 | 352 | 3 |  |
 | Cataldo 2003 [73] | Italy | C&C | 66 | 11 | 225 | 68 | 2 | 232 | 3 |  |
 | Neuhausen 2008 [74] | USA | Cross sectional | 408 | 58 | 1,272 |  |  |  | 3 |  |
AA | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Kakouroru 2007 [75] | Greece | C&C | 157 |  |  | 100 |  |  | 3 | Total number of FDRs and affected FDRs are not specified |
PSO | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 | Criswell 2005 [35] | USA | Cross sectional | 8 | 8 | 232 |  |  |  | 3 |  |