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Table 4 Logistic regression models predicting pregnancy outcomes from metabolite levels

From: Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother–child cohort study

Outcomes

Metabolite

IQR

95% CI

Pvalue

Min

Max

All PB types (n = 114)

Steroid conjugate: 0.63 (s)

1.90

0.99

3.69

0.054

 

Formate

0.51

0.26

0.99

0.047

SPB (n = 88)

Steroid conjugate: 0.63 (s)

1.99

0.94

4.32

0.076

 

Lysine

2.79

1.20

6.98

0.021

 

N-methyl-2-pyridone-5-carboxamide

2.05

0.96

4.51

0.066

 

Formate

0.42

0.19

0.94

0.037

IPB (n = 26)

N-acetyl glycoprotein fragments

5.84

1.44

39.50

0.028

 

Phenylacetylglutamine

0.37

0.09

1.28

0.131

FGR (n = 36)

Tyrosine

0.27

0.08

0.81

0.025

 

Lactate

0.37

0.12

1.04

0.069

 

Alanine

0.38

0.13

1.02

0.064

 

Acetate

0.18

0.04

0.60

0.011

 

Citrate

0.33

0.09

0.99

0.058

 

Trimethylamine

0.14

0.04

0.40

0.001

 

Glycine

0.36

0.11

1.02

0.062

 

Formate

0.24

0.07

0.71

0.014

SGA (n = 19)

Lactate

0.20

0.03

0.89

0.055

 

Alanine

0.19

0.03

0.88

0.055

 

Acetate

0.12

0.01

0.70

0.050

 

N-acetyl neuraminic acid

2.23

0.64

9.10

0.225

 

Glycine

0.19

0.03

0.88

0.052

  1. Interquartile odds ratios (IQR, first versus fourth) with 95% confidence interval (CIs) are presented for the incident risk for pregnancy outcomes according to candidate metabolite relative concentrations.
  2. Statistical analysis (z-score) of the beta values (log odds) indicated if the metabolite was significantly contributing to the model (highlighted in bold).
  3. Models were adjusted for maternal education, maternal age, parity and smoking. FGR, fetal growth restriction; IPB, induced preterm birth; SGA, small for gestational age; SPB, spontaneous preterm birth.