Post-diagnostic medication usage | All cancer patients | Cancer patients with available stage/gradeb | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
All-cause deaths number (%) | Controls number (%) | Unadjusted OR (95% CI) | P(trendd) | AdjustedaOR (95% CI) | P(trendd) | Unadjusted OR (95% CI) | P(trendd) | Fully adjusted OR (95% CI)c | P(trendd) | |
Breast cancer | ||||||||||
ACEI | ||||||||||
0 (non-user) | 1,749 (77.5) | 8,948 (80.2) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||||
≥1 DDD (user) | 509 (22.5) | 2,206 (19.8) | 1.19 (1.06, 1.34) | 0.003 | 1.04 (0.92, 1.19) | 0.51 | 1.19 (1.00, 1.41) | 0.05 | 0.93 (0.76, 1.14) | 0.49 |
(0.01) | (0.60) | (0.09) | (0.37) | |||||||
1 to 365 DDDs | 193 (8.6) | 821 (8.6) | 1.20 (1.02, 1.42) | 0.03 | 1.06 (0.89, 1.27) | 0.52 | 1.26 (0.97, 1.62) | 0.08 | 1.00 (0.76, 1.34) | 0.97 |
≥365 DDDs | 316 (14.0) | 1,385 (12.4) | 1.18 (1.03, 1.36) | 0.02 | 1.03 (0.89, 1.20) | 0.68 | 1.15 (0.94, 1.41) | 0.17 | 0.89 (0.71, 1.13) | 0.34 |
ARB | ||||||||||
0 (non-user) | 2,057 (91.1) | 10,161 (91.1) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||||
≥1 DDD (user) | 201 (8.9) | 993 (8.9) | 1.00 (0.85, 1.18) | 0.99 | 0.96 (0.81, 1.14) | 0.62 | 0.91 (0.71, 1.16) | 0.45 | 0.79 (0.60 ,1.03) | 0.08 |
(0.85) | (0.80) | (0.69) | (0.18) | |||||||
1 to 365 DDDs | 64 (2.8) | 338 (3.0) | 0.93 (0.70, 1.22) | 0.59 | 0.88 (0.66, 1.17) | 0.37 | 0.73 (0.47, 1.15) | 0.18 | 0.62 (0.39, 1.00) | 0.05 |
≥365 DDDs | 137 (6.1) | 655 (5.9) | 1.04 (0.85, 1.26) | 0.71 | 1.00 (0.82, 1.23) | 0.99 | 1.00 (0.75, 1.33) | 0.99 | 0.87 (0.64, 1.19) | 0.38 |
Colorectal cancer | ||||||||||
ACEI | ||||||||||
0 (non-user) | 1,596 (76.0) | 7,578 (75.0) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||||
≥1 DDD (user) | 505 (24.0) | 2,529 (25.0) | 0.96 (0.85, 1.07) | 0.44 | 0.90 (0.79, 1.02) | 0.10 | 0.94 (0.82, 1.07) | 0.36 | 0.89 (0.76, 1.03) | 0.12 |
(0.31) | (0.05) | (0.38) | (0.10) | |||||||
1 to 365 DDDs | 206 (9.8) | 985 (9.8) | 1.00 (0.86, 1.18) | 0.95 | 0.95 (0.80, 1.13) | 0.58 | 0.94 (0.78, 1.14) | 0.55 | 0.92 (0.75, 1.13) | 0.41 |
≥365 DDDs | 299 (14.2) | 1,544 (15.3) | 0.92 (0.80, 1.06) | 0.27 | 0.85 (0.73, 1.00) | 0.05 | 0.94 (0.80, 1.10) | 0.43 | 0.86 (0.72, 1.04) | 0.11 |
ARB | ||||||||||
0 (non-user) | 1,939 (92.3) | 9,294 (92.0) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||||
≥1 DDD (user) | 162 (7.8) | 813 (8.0) | 0.97 (0.82, 1.16) | 0.78 | 0.94 (0.78, 1.13) | 0.50 | 1.01 (0.82, 1.23) | 0.95 | 1.02 (0.82, 1.26) | 0.88 |
(0.88) | (0.86) | (0.66) | (0.72) | |||||||
1 to 365 DDDs | 59 (2.8) | 344 (3.4) | 0.84 (0.64, 1.12) | 0.24 | 0.80 (0.60, 1.06) | 0.12 | 0.85 (0.61, 1.19) | 0.35 | 0.92 (0.65, 1.31) | 0.66 |
≥365 DDDs | 103 (4.9) | 469 (4.6) | 1.07 (0.86, 1.34) | 0.54 | 1.05 (0.83, 1.32) | 0.70 | 1.11 (0.86, 1.41) | 0.42 | 1.07 (0.83, 1.39) | 0.60 |
Prostate cancer | ||||||||||
ACEI | ||||||||||
0 (non-user) | 1,463 (66.6) | 7,512 (69.3) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||||
≥1 DDD (user) | 734 (33.4) | 3,326 (30.7) | 1.14 (1.03, 1.26) | 0.01 | 0.91 (0.82, 1.03) | 0.13 | 1.09 (0.97, 1.23) | 0.15 | 0.88 (0.76, 1.00) | 0.06 |
(0.04) | (0.05) | (0.13) | (0.07) | |||||||
1 to 365 DDDs | 258 (11.7) | 1,098 (10.1) | 1.20 (1.04, 1.40) | 0.01 | 1.00 (0.85, 1.17) | 0.96 | 1.06 (0.89, 1.27) | 0.53 | 0.88 (0.73, 1.07) | 0.20 |
≥365 DDDs | 476 (21.7) | 2,228 (20.6) | 1.11 (0.98, 1.24) | 0.09 | 0.87 (0.76, 0.99) | 0.04 | 1.11 (0.97, 1.27) | 0.14 | 0.87 (0.75, 1.02) | 0.09 |
ARB | ||||||||||
0 (non-user) | 2,002 (91.1) | 9,873 (91.1) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||||
≥1 DDD (user) | 195 (8.9) | 965 (8.9) | 1.00 (0.85, 1.18) | 0.98 | 0.85 (0.72, 1.01) | 0.06 | 1.08 (0.89, 1.30) | 0.45 | 0.92 (0.75, 1.12) | 0.39 |
(0.99) | (0.07) | (0.33) | (0.56) | |||||||
1 to 365 DDDs | 61 (2.8) | 297 (2.7) | 1.02 (0.77, 1.35) | 0.89 | 0.86 (0.64, 1.15) | 0.32 | 0.95 (0.68, 1.33) | 0.77 | 0.81 (0.57, 1.14) | 0.26 |
≥365 DDDs | 134 (6.1) | 668 (6.2) | 0.99 (0.82, 1.21) | 0.95 | 0.84 (0.69, 1.03) | 0.10 | 1.14 (0.91, 1.43) | 0.26 | 0.97 (0.76, 1.23) | 0.81 |