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Table 4 Genetic markers associated with antidepressant response

From: Towards the clinical implementation of pharmacogenetics in bipolar disorder

Drug/Phenotype

Gene

Marker

Subjects

Studies

Diagnosis

Phenotype association

Level of evidence

Antidepressant

GRIK4

rs1954787

1,816

2

MDD

CC genotype associated with better citalopram response

1

HTR2A

rs7997012

1,329

1

MDD

A-allele associated with better citalopram response

1

SLC6A4

5-HTTLPR

1,435

15

MDD, BD

long allele associated with better SSRI response, short allele increases risk of AIM

1

FKBP5

rs4713916

1,426

4

MDD, BD, dysthymia

A-allele associated with better antidepressant response

1

ABCB1

rs2032583, rs2235040

689

2

MDD

C and A alleles respectively associated with better response

1

424

1

MDD

C and A alleles respectively associated with adverse effects

2

  1. AIM, antidepressant induced mania; BD, bipolar disorder; MDD, major depression; SSRI, selective serotonin receptor inhibitor.