From: Towards the clinical implementation of pharmacogenetics in bipolar disorder
Drug/Phenotype | Gene | Marker | Subjects | Studies | Diagnosis | Phenotype association | Level of evidence |
---|---|---|---|---|---|---|---|
Antidepressant | GRIK4 | rs1954787 | 1,816 | 2 | MDD | CC genotype associated with better citalopram response | 1 |
HTR2A | rs7997012 | 1,329 | 1 | MDD | A-allele associated with better citalopram response | 1 | |
SLC6A4 | 5-HTTLPR | 1,435 | 15 | MDD, BD | long allele associated with better SSRI response, short allele increases risk of AIM | 1 | |
FKBP5 | rs4713916 | 1,426 | 4 | MDD, BD, dysthymia | A-allele associated with better antidepressant response | 1 | |
ABCB1 | rs2032583, rs2235040 | 689 | 2 | MDD | C and A alleles respectively associated with better response | 1 | |
424 | 1 | MDD | C and A alleles respectively associated with adverse effects | 2 |