Figure 2
Temperature dependence of 20-(S)-camptothecin transport across Caco-2 cells for basolateral to apical transport. Plot of logarithmic effective permeability (P eff) (mean ± standard deviation) and the best-fit line versus the reciprocal of absolute temperature. Each point represents the mean (± standard deviation) for at least three observations. The activation energy (E a), was determined based on the equation: slope = -E a / 2.303R, where R is the gas constant (= 0.001987 kcal/deg mole).