Skip to main content
Figure 4 | BMC Medicine

Figure 4

From: Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)

Figure 4

Lineweaver–Burk plot (a) and Eadie–Hofstee plot (b) of inhibition of 20-(S)-camptothecin efflux across Caco-2 cells at fixed etoposide concentrations of 0 μM (Δ), 100 μM (•) and 200 μM (□). Each point represents the mean (± standard deviation) for at least three observations. The inhibition constant (K i) was determined from a secondary plot (inset) of the slopes of Lineweaver–Burk plots for various inhibitor concentrations. P eff, effective permeability; V 0, initial rate.

Back to article page