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Figure 6 | BMC Medicine

Figure 6

From: Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)

Figure 6

Inhibition of 20-(S)-camptothecin efflux transport across MDCK II/P-glycoprotein (PGP) cells in the presence of GF120918 (0.2 μM) (a), and across MDCK II/Multidrug Resistance Protein 2 (MRP2) cells in the presence of MK571 (200 μM) (b). Each point represents the mean (± standard deviation) for at least three observations. * Efflux permeability (with inhibitor) is significantly different from the control (without inhibitor), P < 0.05. AP, apical; BL, bisolateral, P eff, effective permeability.

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