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Table 1 Average plasma total and LDL cholesterol concentrations during follow-up

From: The effects of cholesterol lowering with simvastatin on cause-specific mortality and on cancer incidence in 20,536 high-risk people: a randomised placebo-controlled trial [ISRCTN48489393]

Baseline characteristic

Plasma total cholesterol (mmol/l)

Plasma LDL cholesterol (mmol/l)

 

Simvastatin

Placebo

Difference*

Simvastatin

Placebo

Difference*

Sex

      

Male

4.1

5.3

-1.2

2.2

3.2

-1.0

Female

4.6

5.8

-1.2

2.5

3.4

-0.9

Age (years)

      

<65

4.3

5.4

-1.1

2.4

3.2

-0.9

≥65 <70

4.1

5.4

-1.3

2.2

3.3

-1.0

≥70

4.2

5.5

-1.3

2.2

3.3

-1.1

Total cholesterol (mmol/L)

      

<5.0

3.5

4.6

-1.1

1.8

2.6

-0.9

≥5.0 <6.0

4.0

5.2

-1.2

2.1

3.1

-1.0

≥6.0

4.8

6.0

-1.2

2.7

3.7

-1.0

LDL cholesterol (mmol/L)

      

<3.0

3.7

4.9

-1.1

1.8

2.7

-0.9

≥3.0 <3.5

4.1

5.3

-1.2

2.2

3.2

-1.0

≥3.5

4.7

5.9

-1.2

2.7

3.7

-1.0

ALL PATIENTS

4.2

5.4

-1.2

2.3

3.3

-1.0

  1. * Intention-to-treat comparisons with missing data imputed from initial pre-treatment screening values. The absolute difference in LDL-cholesterol that would be produced by full compliance with 40 mg simvastatin daily can be estimated as the ratio of the absolute difference to the estimated compliance. For example, -1.0/67% = -1.5 mmol/L.