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Table 2 Montreal Neurological Institute (MNI) Coordinates for peak activation differences (p < 0.01; uncorrected) for the random-effects group analysis between ε3/4 heterozygotes and ε3/3 homozygotes for the functional MRI encoding contrast of novel versus familiar pictures. k = cluster size

From: Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's Disease: a cross-sectional study

Contrast

Region (k)

Montreal Neurological Institute (MNI) coordinates

Peak t value

P (uncorrected)

  

x

y

z

  

Novel vs. Familiar

      

ε3/3 > ε3/4

Right anterior entorhinal cortex (60)

22

2

-34

3.56

0.001

 

- Right parahippocampal gyrus

22

-8

-34

2.99

0.002

 

Right hippocampus (93)

30

-14

-16

3.01

0.002

 

- Right hippocampus

36

-24

-6

2.99

0.003