Superior efficacy of St John's wort extract WS®5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]

Table 2 Comparison of HAM-D scores for patients with a major depressive episode over 6-week treatment with WS^® 5570 or placebo (full analysis set; last observation carried forward)

HAM-D measure		WS^® 5570 600 mg/day N = 119	WS^® 5570 1200 mg/day N = 124	Placebo N = 81	p-value
					WS^® 5570 600 mg/day vs placebo	WS^® 5570 1200 mg/day vs placebo
Total score (mean ± SD)	Day 0	22.8 ± 3.3	22.6 ± 3.8	23.6 ± 4.2	0.14	0.09
	Day 14	17.9 ± 6.3	18.2 ± 6.6	19.1 ± 20	0.23	0.34
	Day 42	11.2 ± 7.0	11.8 ± 8.3	17.6 ± 8.8	<0.001	<0.001
Difference vs day 0 (mean ± SD)	Day 14	-4.9 ± 5.1	-4.5 ± 4.7	-4.5 ± 5.4	0.65	0.95
	Day 42	-11.6 ± 6.4	-10.8 ± 7.3	-6.0 ± 8.1	<0.001	<0.001
Mean reduction vs day 0 (%)	Day 14	22.0%	20.9%	16.7%	0.54	0.77
	Day 42	57.9%	57.1%	16.7%	<0.001	<0.001
Comparison vs placebo for difference day 42 vs day 0		WS ^® 5570 600 mg/day vs placebo		WS ^® 5570 1200 mg/day vs placebo
Differences in means*		-5.6		-4.8
95% confidence interval		[-7.7, -3.6]		[-6.9, -2.6]
p-value		<0.001		<0.001

*A negative difference denotes a more favorable outcome in the treatment group named first.

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