Skip to main content

Table 3 Effect estimates (odds ratios) for spina bifida-affected pregnancies associated with maternal choline intake, CHKA SNP hCV1562388 (A>C), hCV1562393(C>G), PCYT1A SNPs rs939883 (T>A) and rs3772109 (T>C) genotypes. Breslow-Day test: P > 0.05. Lower 25%: total choline intake ≤ 289.93 mg/day. Higher 75 %: total choline intake > 513.24 mg/day.

From: CHKA and PCYT1Agene polymorphisms, choline intake and spina bifida risk in a California population

CHKA gene

Cases

Controls

OR

(95% CI)

SNP hCV1562388 (A>C)

Lower 25 percentile

  

Reference

 

AA

17

35

  

AC + CC

15

49

0.63

0.28–1.63

Higher 75 percentile

  

Reference

 

AA

37

103

  

AC + CC

31

148

0.58

0.34–1.00

SNP hCV1562393(C>G)

Lower 25 percentile

  

Reference

 

CC

22

58

 

-

CG + GG

9

25

1.08

0.43–2.70

Higher 75 percentile

  

Reference

 

CC

44

167

 

-

CG + GG

23

83

1.05

0.60–1.86

PCYT1A gene

Cases

Controls

OR

95% CI

SNP rs939883 (T>A)

Lower 25 percentile

  

Reference

 

TT

9

37

  

TA

17

35

1.23

0.43–3.52

AA

7

11

1.66

0.41–3.52

Higher 75 percentile

  

Reference

 

TT

26

95

  

TA

31

126

0.90

0.50–1.61

AA

12

27

1.62

0.72–3.64

SNP rs3772109 (T>C)

Lower 25 percentile

  

Reference

 

TT

9

27

  

TC

17

40

1.28

0.50–3.28

CC

5

16

0.94

0.27–3.29

Higher 75 percentile

  

Reference

 

TT

24

77

  

TC

34

124

0.88

0.49–1.59

CC

10

49

0.59

0.25–1.37