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Figure 2 | BMC Medicine

Figure 2

From: Methodological issues in detecting gene-gene interactions in breast cancer susceptibility: a population-based study in Ontario

Figure 2

Example of partitions of two-locus genotypes with the three methods. (a-d) The four partitions identified by MDR for the XPD-CYP17 two-locus genotypes. (e) The best partition found by MDR for the COMT-CCDN1 two-locus genotypes. (f) The best partition found by CART for the CYP17-BARD1 two-locus genotypes. Shaded cells are classified as high-risk and non-shaded cells as low-risk. This corresponds to a ratio of cases versus controls higher or lower than 1, respectively. The four partitions of the two-locus genotypes found by MDR showed two cells with different assignments. In (f), CART can partition the two-locus genotypes in more than two groups, but for the purpose of comparison with MDR, we used the same high-risk/low-risk grouping.

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BMC Medicine

ISSN: 1741-7015

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