Table 3 Interactions selected by MDR with permutation P-value less than 5%
Rank | Interactions | Testing accuracy* | Permutation P-value |
|---|---|---|---|
1 | IL1A-[Ala114Ser] XPD-[Lys751Gln] IL10-[G(-1082)A] | 58.2% | <0.001 |
2 | ESR1-[Ser10Ser] CYP17-[C(518)T] IL10-[G(-1082)A] COMT-[Met108/158Val] PTEN- [(IVS4+109)ins/del5] CCND1-[Pro241Pro] | 60.2% | <0.001 |
3 | CYP17-[C(518)T] BARD1-[Pro24Ser] COMT-[Met108/158Val] MMP1-[1G(-1607)2G] CCND1-[Pro241Pro] | 58.4% | 0.001 |
4 | IL13-[Arg130Gln] XPD-[Lys751Gln] IL10-[G(-1082)A] | 57.5% | 0.002 |
5 | CYP17-[C(518)T] XPD-[Lys751Gln] GSTP1-[Ile105Val] GADD45-[C(IVS3+168)T] | 56.7% | 0.006 |
6 | XPD-[Lys751Gln] IL10-[G(-1082)A] GSTP1-[Ile105Val] COMT-[Met108/158Val] MMP1-[1G(-1607)2G] CCND1-[Pro241Pro] | 57.5% | 0.006 |
7 | ESR1-[Ser10Ser] XPD-[Lys751Gln] IL10-[G(-1082)A] MMP1-[1G(-1607)2G] PTEN-[(IVS4+109)ins/del5 | 57.2% | 0.007 |
8 | CYP17-[C(518)T] XPD-[Lys751Gln] IL10-[G(-1082)A] MTHFR-[Ala222Val] COMT-[Met108/158Val] CCND1-[Pro241Pro] | 58.2% | 0.007 |
9 | XPD-[Lys751Gln] IL10-[G(-1082)A] | 55.9% | 0.009 |
10 | CYP17-[C(518)T] XPD-[Lys751Gln] IL10-[G(-1082)A] MTHFR-[Ala222Val] COMT-[Met108/158Val] | 56.3% | 0.016 |
11 | BARD1-[Pro24Ser] XPD-[Lys751Gln] IL10-[G(-1082)A] | 55.6% | 0.017 |
12 | ESR1-[Ser10Ser] XPD-[Lys751Gln] MMP1-[1G(-1607)2G] PTEN-[(IVS4+109)ins/del5 | 55.9% | 0.017 |
13 | COMT-[Met108/158Val] CCND1-[Pro241Pro] | 55.2% | 0.019 |
14 | CYP17-[C(518)T] IL10-[G(-1082)A] COMT-[Met108/158Val] PTEN-[(IVS4+109)ins/del5] CCND1-[Pro241Pro] | 55.7% | 0.020 |
15 | IL10-[G(-1082)A] MTHFR-[Ala222Val] GSTP1-[Ile105Val] COMT-[Met108/158Val] | 55.7% | 0.023 |
16 | IL13-[Arg130Gln] CYP17-[C(518)T] | 54.5% | 0.037 |
17 | BARD1-[Pro24Ser] XPD-[Lys751Gln] | 54.7% | 0.037 |
18 | CYP17-[C(518)T] XPD-[Lys751Gln] IL10-[G(-1082)A] COMT-[Met108/158Val] PTEN- [(IVS4+109)ins/del5] CCND1-[Pro241Pro] | 55.9% | 0.046 |