From: The influence of gender on the effects of aspirin in preventing myocardial infarction
Author (year) | Trial name | Participants | Sample size | Mean age at baseline (year) | Current smoker (%) | Male (%) | Follow-up (year) | Aspirin dose (mg/day) |
---|---|---|---|---|---|---|---|---|
Ridker et al [26] (2005) | Women's Health Study (WHS) | Healthy women ≥ 45 years in USA | 39 876 | 55 | 13 | 0 | 10.0 | 100† |
de Gaetano [19] (2001) | Primary Prevention Project (PPP) | Patients with at least one of the major recognized cardiovascular risk factors in Italy | 4 495 | 64 | 15 | 42 | 3.6 | 100 |
Cote et al [18] (1995) | Asymptomatic Cervical Bruit Study (ACBS) | Patients with asymptomatic carotid stenosis in Canada | 372 | 67 | 37 | 45 | 2.3 | 325 |
ETDRS Study Group [13] (1992) | Early Treatment Diabetic Retinopathy Study report (ETDRS) | Patients with a clinical diagnosis of diabetes mellitus | 3 711 | 18–70 | 44# | 52 | 5.0 | 650 |
Juul-Moller et al [24] (1992) | Swedish Angina Pectoris Aspirin Trial (SAPAT) | Patients with chronic stable angina | 2 035 | 67 | 16 | 52 | 4.2 | 75 |
Hansson et al [23] (1998) | Hypertension Optimal Treatment Study (HOT) | Patients with hypertension and diastolic blood pressure between 100 mmHg and 115 mmHg from countries in Europe, America, and Asia | 18 790 | 62 | 16 | 53 | 3.8 | 75 |
Swedish cooperative [8] (1987) | Swedish Cooperative Study (Swedish Coop) | Patients with cerebral infarction, minor or major stroke | 505 | 68 | 52 | 62 | 2.0 | 1 500 |
EAFT Study Group [14] (1993) | European Atrial Fibrillation Trial (EAFT) | Patients with non-rheumatic atrial fibrillation | 782* | 73 | 19 | 63 | 2.3 | 300 |
SALT Collaborative Group [11] (1991) | Swedish Aspirin Low-Dose Trial (SALT) | Patients after transient ischaemic attack (TIA) or minor stroke | 1 360 | 67 | 25 | 66 | 2.7 | 75 |
Cairns et al [17] (1985) | Canadian multicenter trial (Canadian) | Patients with unstable angina who were hospitalized in coronary care units in Canada | 278* | 57 | 35 | 70 | 1.5 | 1 300 |
Stroke Prevention in Atrial Fibrillation Study group [12] (1991) | Stroke Prevention in Atrial Fibrillation Study (SPAF) | Patients with constant or intermittent atrial fibrillation | 1 120* | 67 | 16 | 71 | 1.3 | 325 |
Sorensen et al [27] (1983) | A Danish cooperative study (Danish Coop) | Patients experienced at least one reversible cerebral ischemic attack | 203 | 59 | 24¶ | 73 | 2.0 | 1 000 |
Farrell et al [22] (1991) | United Kingdom transient ischaemic attack aspirin trial (UK-TIA) | Patients with a transient ischaemic attack or minor ischaemic stroke | 2 435 | 60 | 53 | 73 | 4.0 | 300/1 200 |
Persantine-Aspirin Reinfarction Study Research Group [5] (1980) | Persantine-aspirin Reinfarction Study (PARIS) | Patients recovered from myocardial infarction | 1 216* | 56 | 27 | 77 | 3.4 | 972 |
Breddin et al [16] (1980) | German-Austrian aspirin trial (GAAT) | Patients who had survived a myocardial infarction for 30–42 days | 626 | 45–70 | 58 | 78 | 2.0 | 1 500 |
Elwood and Sweetnam [21] (1979) | Aspirin and secondary mortality after myocardial infarction (Cardiff-II) | Patients with confirmed myocardial infarction | 1 725‡ | 56 | 60 | 85 | 1.0 | 900 |
AMIS Study Group [6] (1980) | Aspirin myocardial infarction study (AMIS) | Patients experienced at least one myocardial infarction in USA | 4 524 | 55 | 27 | 89 | 3.0 | 1 000 |
Elwood et al [20] (1974) | Secondary prevention of mortality from myocardial infarction (Cardiff-I) | Patients with recent myocardial infarction | 1 239‡ | 55 | NA | 100 | 1.1 | 300 |
Coronary Drug Project Research Group [7] (1980) | Coronary Drug Project Aspirin Study (CDPA) | Patients with a history of myocardial infarction | 1 529‡ | NA | NA | 100 | 1.8 | 324 |
Lewis et al [25] (1983) | Veterans Administration Cooperative Study (VACS) | Patients with unstable angina in USA | 1 266 | 56 | 50 | 100 | 1.0 | 324 |
Steering Committee of the Physicians' Health Study Research Group [9] (1989) | Physicians' Health Study (PHS) | Healthy male physicians in USA | 22 071 | 52 | 11 | 100 | 5.0 | 325† |
The RISC Group [10] (1990) | Research Group on Instability in Coronary Artery Disease (RISC) | Men with unstable coronary artery disease in Southeast Sweden | 796* | 58 | 38 | 100 | 1.0 | 75 |
Medical Research Council's General Practice Research Framework Group [15] (1998) | Thrombosis prevention Trial (TPT) | Patients at high risk of cardiovascular disease in UK | 2 540 | 58 | 41 | 100 | 4.0 | 75 |