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Table 4 Top SNPs ranked by univariate analysis for trial E9486.

From: Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival

Rank

rs ID

pval

Gene Sym

Gene Name

SNP Function

1.0

rs10018625

0.001536

TAG ERROR

TAG ERROR

unknown, TAG ERROR

2.0

rs1047643

0.001603

FDFT1

Farnesyl-diphosphate farnesyltransferase 1

coding-synon

3.0

rs20541

0.001644

IL13

Interleukin 13

coding-nonsynon

4.0

rs2108622

0.0020374

CYP4F2

Cytochrom P450, family 4, subfamily F, polypeptide 2

coding-nonsynon

5.0

rs3759259

0.002362

STYK1

Protein kinase STYK1

coding-nonsynon

6.0

rs1801133

0.003251

MTHFR

5, 10-methylenetetrahydrofolate reductase (NADPH)

coding-nonsynon

7.0

rs2069456

0.003375

CDK5

Cyclin-dependent kinase 5

intron

8.0

rs1131532

0.005650

TNFSF10

Tumor necrosis factor (ligand) superfamily, member 10

coding-synon

9.0

rs882709

0.005965

SETX

senataxin

coding-nonsynon

10.0

rs4646421

0.007847

CYP1A1

Cytochrome P450, family 1, subfamily A, polypeptide 1

intron

11.0

rs1799969

0.008221

ICAM1

Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor

coding-nonsynon

12.0

rs3822430

0.009157

SRD5A1

Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

coding-synon

13.0

rs7903344

0.009471

CHUK

Conserved helix-loop-helix ubiquitous kinase

coding-nonsynon

14.0

rs13926

0.011531

TRAP1

TNF receptor-associated protein 1

coding-nonsynon

15.0

rs3172469

0.012006

BCL6

B-cell CCL/lymphoma 6 (zinc finger protein 51)

intron

16.0

rs215101

0.012028

ABCC1

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

intron, TagSNP:ABCC1

17.0

rs2227564

0.012246

PLAU

Plasminogen activator, urokinase

coding-nonsynon

18.0

rs3096057

0.012484

CSF1

Colony stimulating factor 1 (macrophage)

Promoter

19.0

rs6474491

0.013935

STAR

Steriodogenic acute regulator

Promoter

20.0

rs2066471

0.015231

MTHRF

5, 10-methlyenetetrahydrofolate reductase (NADPH)

intron