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Table 2 Direct comparison between the two mutants (C99I45F versus C99V50F) showed CRABP1 as up-regulated in C99I45F (Aβ42/Aβ40↑) whereas neurofilaments were not differentially expressed

From: Upregulation of CRABP1 in human neuroblastoma cells overproducing the Alzheimer-typical Aβ42reduces their differentiation potential

Name

Fold change C99I45F/C99V50F

P-value

 

Transcriptomics

Proteomics

Transcriptomics

Proteomics

CRABP1

2.3

2.8

0.188

0.059

NEF3

1.1

-1.1

0.790

0.56

NEFL

1.1

-1.1

0.640

0.51

INA

1.1

-1.1

0.679

0.24

  1. Direct comparison of C99I45F and C99V50F (baseline experiment, C99V50F) revealed effects mediated by an altered Aβ42/Aβ40 ratio for CRABP1 by a fold change distinctly deviating from 1.0, and an effect mediated by C99 for neurofilament 3 (NEF3), neurofilament light polypeptide 68 kDa (NEFL) and internexin neuronal intermediate filament protein alpha (INA) by a fold change close to 1.0, because C99 was approximately equally expressed in both mutants. Significance was determined performing an unpaired t-test for the direct comparison of both mutants. As to be expected, p-values were high for not differentially expressed genes [62, 63].
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BMC Medicine

ISSN: 1741-7015

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