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Table 2 Real-time quantitative PCR analysis.

From: Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy

 

SMA I

SMA III

Gene

Expression value

Expression value

IGF-1R

+3.2

-2.9

FRAP1

(MTOR)

1

+2.8

FOXO3A

+1.3

-1.6

eIF4EBP1

-1.4

-1.7

FBOX32

(Atrogin-1)

-1.6

-1.7

TRAF2

1

+4.2

MAPK14

(p38)

-1.25

+1.6

RRAS2

-2

-2.5

MAPK1

(ERK)

+1.2

+2.4

  1. Expression ratios of selected intracellular signaling molecules of atrophy and hypertrophy pathways tested in affected SMAI and III muscles versus control muscles (p < 0.05).
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BMC Medicine

ISSN: 1741-7015

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