Table 2 Gene list predicting sensitivity (S) or resistance (R) to PG-11047 treatment.
From: A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047
Gene symbol | P-value | Predict | Chromosome location | Gene name | Function | References |
|---|---|---|---|---|---|---|
WASL | 2.5E-05 | R | chr7q31.3 | Wiskott-Aldrich syndrome-like | Key regulator of cell migration and actin polymerization by interaction with Ap2/3 complex | |
GCLM | 4.7E-05 | S | chr1p22.1 | Glutamate-cysteine ligase, modifier subunit | Regulatory subunit of glutamate-cystein ligase, a rate-limiting enzyme catalyzing the first step of GSK biosynthesis from cysteine | [39] |
CST3 | 6.3E-05 | R | chr20p11.21 | Cystatin C (amyloid angiopathy and cerebral haemorrhage) | Potent inhibitor of lysosomal proteinases. TGFβ receptor antagonist, inhibit epithelial-mesenchymal transition and morphological transformation | [30] |
LAMA3 | 6.7E-05 | S | chr18q11.2 | Laminin, alpha 3 | Component of laminin 5, the major extracellular metrix protein produced in the basement membrane of the mammary epithelial cells. Induces motility, invasion and epithelial-mesenchymal transition | |
SSRP1 | 1.2E-04 | S | chr11q12 | Structure specific recognition protein 1 | Histone chaperone. Forms a heterodimer with Spt16 and is a component of the chromatin transcript regulation factor, FACT | |
ACYP1 | 1.2E-04 | S | chr14q24.3 | Acylphosphatase 1, erythrocyte (common) type | Catalyze the hydroolysis of acylphosphates | [49] |
CYLD | 2.9E-04 | S | chr16q12.1 | Cylindromatosis (turban tumour syndrome) | A deubiquinating enzyme that negatively regulate the activity of NFkB and JNK. Regulate mitotic entry | |
PRPF18 | 3.0E-04 | S | chr10p13 | PRP18 pre-mRNA processing factor 18 homolog (Saccharomyces cerevisiae) | Participate in pre-mRNA splicing, prepare mRNA for translation | [41] |
AMFR | 3.1E-04 | S | chr16q21 | Autocrine motility factor receptor | Receptor for AMF, a tumour motility-stimulating protein secreted by tumour cells. Stimulation of AMFR by AMF alters cellular adhesion, proliferation, motility and apoptosis | |
DEAF1 | 7.9E-04 | R | chr11p15.5 | Deformed epidermal autoregulatory factor 1 (Drosophila) | A sequence-specific DNA-binding protein required for development. May be a general regulator of gene transcription/expression. DEAF1 (also called 'suppressin') appear to be mutated in tumours and cell lines | |
PPP1R2 | 1.5E-03 | S | chr3q29 | Protein phosphatase 1, regulatory (inhibitor) subunit 2 | Inhibitor of protein phosphatase 1. Phosphorylation of PPP1R2 by glycogen synthase kinase-3 (GSK3) activates the enzyme. PPP1R2 (INH2) regulates PP1 complexed with NEK2 to induce centrosome separation | [44] |
LOH11CR2A | 1.7E-03 | S | chr11q23 | Loss of heterozygosity, 11, chromosomal region 2, gene A | Frequent loss of heterozygosity at 11q23 region found in many tumour types | [46] |
ACSL3 | 1.8E-03 | R | chr2q34-q35 | Acyl-CoA synthetase long-chain family member 3 | Essential for fatty acid metabolism, providing activated intermediates for complex lipid synthesis, protein modification, and beta oxidation | [52] |