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Table 2 Cox proportional hazards models for relapse-free survival using the NKI 295 patient test data set – model containing the clinical variables and multiple gene expression profiles

From: A compact VEGF signature associated with distant metastases and poor outcomes

Variable

DF

Estimate

Standard Error

Chi-Square

Pr > ChiSq

Hazard Ratio

95% Hazard Ratio Confidence Limits

Age

1

-0.0505

0.0174

8.4217

0.0037

0.951

0.919

0.984

ER

1

-0.5654

0.34723

2.6514

0.1035

0.568

0.288

1.122

Grade2vs1

1

0.15563

0.33471

0.2162

0.642

1.168

0.606

2.252

Grade3vs1

1

0.02327

0.36156

0.0041

0.9487

1.024

0.504

2.079

Tsize

1

0.53014

0.19935

7.0723

0.0078

1.699

1.15

2.511

node

1

0.15863

0.19203

0.6824

0.4087

1.172

0.804

1.707

Treatment

1

-0.63284

0.29747

4.526

0.0334

0.531

0.296

0.951

VEGF_3group

1

0.47637

0.1597

8.8972

0.0029

1.61

1.177

2.202

GHI

1

0.24924

0.22057

1.2769

0.2585

1.283

0.833

1.977

Gene70

1

0.6283

0.33298

3.5605

0.0592

1.874

0.976

3.6

Wound_Response

1

0.8087

0.35969

5.0549

0.0246

2.245

1.109

4.543

LumA_LumB

1

0.74421

0.36168

4.2339

0.0396

2.105

1.036

4.276

LumA_Basal

1

-0.68615

0.48782

1.9785

0.1596

0.504

0.194

1.31

LumA_Her2- enrich

1

-0.16349

0.45232

0.1306

0.7178

0.849

0.35

2.061

LumA_Normal

1

0.51006

0.37635

1.8368

0.1753

1.665

0.796

3.482

ER-regulated

1

0.02629

0.32219

0.0067

0.935

1.027

0.546

1.93

TP53-associated

1

-0.0764

0.31658

0.0582

0.8093

0.926

0.498

1.723