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Table 1 Gene ontology terms for genes up-regulated in CCL-171 cells by insulin-like growth factor (IGF-I).

From: IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients

Gene ontology term

Cluster frequency

Gene frequency in background

Corrected

P-value

FDR

False positives

M phase

42 out of 325 genes, 12.9%

67 out of 2133 genes, 3.1%

1.84E-16

0.0%

0.0

Cell cycle phase

45 out of 325 genes, 13.8%

82 out of 2133 genes, 3.8%

1.46E-14

0.0%

0.0

Cell division

38 out of 325 genes, 11.7%

69 out of 2133 genes, 3.2%

5.07E-12

0.0%

0.0

M phase of mitotic cell cycle

32 out of 325 genes, 9.8%

52 out of 2133 genes, 2.4%

1.06E-11

0.0%

0.0

Cell cycle process

50 out of 325 genes, 15.4%

113 out of 2133 genes, 5.3%

2.13E-11

0.0%

0.0

Nuclear division

31 out of 325 genes, 9.5%

51 out of 2133 genes, 2.4%

4.65E-11

0.0%

0.0

Mitosis

31 out of 325 genes, 9.5%

51 out of 2133 genes, 2.4%

4.65E-11

0.0%

0.0

Cell cycle

57 out of 325 genes, 17.5%

143 out of 2133 genes, 6.7%

7.11E-11

0.0%

0.0

Organelle fission

31 out of 325 genes, 9.5%

52 out of 2133 genes, 2.4%

9.95E-11

0.0%

0.0

Mitotic cell cycle

39 out of 325 genes, 12.0%

86 out of 2133 genes, 4.0%

7.94E-09

0.0%

0.0

Organelle organization

67 out of 325 genes, 20.6%

217 out of 2133 genes, 10.2%

4.21E-07

0.0%

0.0

Cellular component organization

91 out of 325 genes, 28.0%

358 out of 2133 genes, 16.8%

1.78E-05

0.0%

0.0

Microtubule-based process

21 out of 325 genes, 6.5%

40 out of 2133 genes, 1.9%

2.56E-05

0.0%

0.0

Regulation of mitotic cell cycle

17 out of 325 genes, 5.2%

31 out of 2133 genes, 1.5%

2.40E-04

0.0%

0.0

Spindle organization

10 out of 325 genes, 3.1%

14 out of 2133 genes, 0.7%

2.70E-03

0.4%

0.1

Microtubule-based Movement

10 out of 325 genes, 3.1%

15 out of 2133 genes, 0.7%

0.01

0.6%

0.1

Mitotic cell cycle checkpoint

9 out of 325 genes, 2.8%

13 out of 2133 genes, 0.6%

0.01

0.6%

0.1

Regulation of cell cycle

27 out of 325 genes, 8.3%

79 out of 2133 genes, 3.7%

0.01

0.6%

0.1

Biological regulation

152 out of 325 genes, 46.8%

785 out of 2133 genes, 36.8%

0.04

0.6%

0.1

Microtubule cytoskeleton organization

12 out of 325 genes, 3.7%

24 out of 2133 genes, 1.1%

0.05

0.7%

0.1

  1. Detailed list of gene ontology terms specifically up-regulated in CCL-171 fibroblasts upon IGF-I stimulation in comparison to background file including all genes deregulated by IGF-I. Bonferroni corrected p values for of the output from GO::Termfinder for process ontology are listed.
  2. FDR, false discovery rate.