Skip to main content

Table 2 Gene ontology terms for genes up-regulated in breast fibroblasts by insulin-like growth factor-1 (IGF-I).

From: IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients

Gene Ontology term

Cluster frequency

Gene frequency in background

Corrected P-value

FDR

False positives

M phase

36 out of 186 genes, 19.4%

175 out of 8918 genes, 2.0%

2.00E-23

0%

0.00

Cell cycle phase

37 out of 186 genes, 19.9%

223 out of 8918 genes, 2.5%

1.18E-20

0%

0.00

Cell cycle process

41 out of 186 genes, 22.0%

314 out of 8918 genes, 3.5%

4.69E-19

0%

0.00

Nuclear division

28 out of 186 genes, 15.1%

128 out of 8918 genes, 1.4%

1.64E-18

0%

0.00

Mitosis

28 out of 186 genes, 15.1%

128 out of 8918 genes, 1.4%

1.64E-18

0%

0.00

Cell cycle

46 out of 186 genes, 24.7%

425 out of 8918 genes, 4.8%

2.85E-18

0%

0.00

M phase of mitotic cell cycle

28 out of 186 genes, 15.1%

131 out of 8918 genes, 1.5%

3.21E-18

0%

0.00

Organelle fission

28 out of 186 genes, 15.1%

133 out of 8918 genes, 1.5%

4.99E-18

0%

0.00

Mitotic cell cycle

33 out of 186 genes, 17.7%

229 out of 8918 genes, 2.6%

3.30E-16

0%

0.00

Cell division

28 out of 186 genes, 15.1%

164 out of 8918 genes, 1.8%

1.88E-15

0%

0.00

Microtubule-based process

24 out of 186 genes, 12.9%

130 out of 8918 genes, 1.5%

8.42E-14

0%

0.00

Microtubule-based movement

13 out of 186 genes, 7.0%

47 out of 8918 genes, 0.5%

3.61E-09

0%

0.00

Spindle organization

10 out of 186 genes, 5.4%

27 out of 8918 genes, 0.3%

3.73E-08

0%

0.00

Cytoskeleton-dependent intracellular transport

13 out of 186 genes, 7.0%

56 out of 8918 genes, 0.6%

4.11E-08

0%

0.00

Organelle organization

44 out of 186 genes, 23.7%

737 out of 8918 genes, 8.3%

6.24E-08

0%

0.00

Chromosome segregation

10 out of 186 genes, 5.4%

41 out of 8918 genes, 0.5%

3.83E-06

0%

0.00

Microtubule cytoskeleton organization

12 out of 186 genes, 6.5%

70 out of 8918 genes, 0.8%

8.84E-06

0%

0.00

Phosphoinositide-mediated signalling

8 out of 186 genes, 4.3%

27 out of 8918 genes, 0.3%

2.32E-05

0%

0.00

Mmitotic sister chromatid segregation

7 out of 186 genes, 3.8%

22 out of 8918 genes, 0.2%

9.41E-05

0%

0.00

Sister chromatid segregation

7 out of 186 genes, 3.8%

22 out of 8918 genes, 0.2%

9.41E-05

0%

0.00

Cellular component organization

50 out of 186 genes, 26.9%

1187 out of 8918 genes, 13.3%

3.40E-04

0%

0.00

Regulation of mitotic cell cycle

10 out of 186 genes, 5.4%

72 out of 8918 genes, 0.8%

1.03E-03

0%

0.00

Second-messenger-mediated signalling

8 out of 186 genes, 4.3%

44 out of 8918 genes, 0.5%

1.36E-03

0%

0.00

Regulation of cell cycle

16 out of 186 genes, 8.6%

197 out of 8918 genes, 2.2%

1.68E-03

0%

0.00

Cytoskeleton organization

16 out of 186 genes, 8.6%

198 out of 8918 genes, 2.2%

1.80E-03

0%

0.00

Protein polymerization

6 out of 186 genes, 3.2%

23 out of 8918 genes, 0.3%

2.63E-03

0%

0.00

Positive regulation of mitosis

4 out of 186 genes, 2.2%

7 out of 8918 genes, 0.1%

2.73E-03

0%

0.00

Amino acid biosynthetic process

6 out of 186 genes, 3.2%

25 out of 8918 genes, 0.3%

4.45E-03

0%

0.00

Chromosome localization

4 out of 186 genes, 2.2%

8 out of 8918 genes, 0.1%

0.01

0%

0.00

Establishment of chromosome localization

4 out of 186 genes, 2.2%

8 out of 8918 genes, 0.1%

0.01

0%

0.00

Cell cycle checkpoint

7 out of 186 genes, 3.8%

47 out of 8918 genes, 0.5%

0.02

0%

0.04

Establishment of localization in cell

24 out of 186 genes, 12.9%

472 out of 8918 genes, 5.3%

0.02

0%

0.04

Cellular localization

25 out of 186 genes, 13.4%

507 out of 8918 genes, 5.7%

0.03

0%

0.04

DNA metabolic process

17 out of 186 genes, 9.1%

275 out of 8918 genes, 3.1%

0.03

0%

0.06

Amine biosynthetic process

6 out of 186 genes, 3.2%

35 out of 8918 genes, 0.4%

0.03

0%

0.08

Serine family amino acid biosynthetic process

3 out of 186 genes, 1.6%

5 out of 8918 genes, 0.1%

0.04

0%

0.08

  1. Detailed information and P values for single biological processes up-regulated by IGF-I in primary breast fibroblasts in comparison to background file including all genes used for significant analysis of mcroarray analysis as revealed by gene ontology term finder tool with a Bonferoni corrected P value higher than 0.05.
  2. FDR, false discovery rate.