Table 4 Univariate and multivariate (backward conditional selection) Cox regression analysis of metastasis-free survival (MFS) in breast cancer patients considering clinicopathological characteristics, tumour microvessel density and hypoxia inducible factor 1α (HIF-1α)TAGmRNA levels
Characteristics | Univariate analysis of MFS, Exp B (95% CI) | Pvalue | Multivariate analysis of MFS, Exp B (95% CI) | Pvalue |
|---|---|---|---|---|
Age, years: | ||||
< 50 | 1 | 0.561 | ||
≥ 50 | 1.32 (0.52 to 3.37) | |||
Positive lymph node: | ||||
0 | 1 | 0.003 | 1 | 0.005 |
1 to 3 | 8.00 (2.56 to 24.81) | 5.56 (1.75 to 17.63) | ||
4 to 9 | 7.50 (1.70 to 30.00) | 6.68 (1.48 to 30.14) | ||
> 10 | 1.20 (0.14 to 10.00) | 0.48 (0.05 to 4.25) | ||
Pathological tumour size, mm: | ||||
< 10 | 1 | 0.39 | ||
10 to 20 | 1.10 (0.10 to 8.70) | |||
21 to 49 | 2.40 (0.30 to 18.90) | |||
> 50 | 2.70 (0.20 to 42.90) | |||
Tumour grade: | ||||
1/2 vs | 1 | 0.24 | ||
3 | 1.70 (0.70 to 4.40) | |||
Peritumoural vascular invasion: | ||||
Absent | 1 | 0.104 | ||
Present | 3.40 (0.80 to 14.80) | |||
OR status: | ||||
Positive | ||||
Negative | 0.33 (0.13 to 0.85) | 0.021 | ||
PgR status: | ||||
Positive | ||||
Negative | 0.20 (0.07 to 0.60) | 0.005 | 0.23 (0.07 to 0.72) | 0.012 |
Tumour microvessel density | 1.02 (0.07 to 0.60) | 0.22 | ||
HIF-1α TAGmRNA levels | 1.03 (1.00 to 1.05) | 0.01 |