Table 2 Antiemetic agents and supposed dosage in hyperemesis gravidarum, adapted from references [13, 62, 98]
From: Managing hyperemesis gravidarum: a multimodal challenge
Food and Drug Admnistration category | Medication | Administration | Suggested dosage |
|---|---|---|---|
A | Pyridoxine (vitamin B6) | Oral | 20 mg 3 × per day (max. dose: 200 mg per day) |
| Â | Doxylamine | Oral | 25 mg at night and 12.5 mg in the morning accompanied by 10 mg of pyridoxine (maximum dose: 80 mg per day) |
B | Ondansetron | Oral/intravenously (IV) | 4-8 mg 2-3× per day/2-4 mg every 6-8 h or 8 mg every 12 h IV |
|  | Metoclopramide | Oral | 5-10 mg 3-4 × per day |
|  | Meclizine | Oral/rectal | 25-100 mg 2-4 × per day/1 × per day |
| Â | Diphenhydramine | Oral/IV | 25-50 mg every 6-8 h |
|  | Dimenhydrinate | Oral/IV/rectal | 50 mg 3-4× per day/62 mg 2× per day/1-3× per day |
C | Promethazine | Oral/IV | 12.5-25 mg up to 6 × per day |
|  | Prochlorperazine | Rectal | 25 mg per day or 2× per day |
| Â | Prednisolone | Oral | 40-60 mg per day reducing by half every 3 days |
- | Ginger | Oral (biscuits, confectionary, crystals, powder, tablets, capsules, fresh ginger) | Up to 1 g per day in divided doses |