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Table 2 Clinical characteristics of the study sample.

From: An evaluation of inflammatory gene polymorphisms in sibships discordant for premature coronary artery disease: the GRACE-IMMUNE study

 

Unaffected

Affected

  

Risk factor

N(%)

N(%)

Univariate

P-value *

Multivariable

OR†

Total sample

1545 (100)

1154 (100)

-

-

Male sex

630 (40.8)

873 (75.7)

<0.0001

4.71 (3.65, 6.08)

Diabetes mellitus

62 (4.0)

117 (10.1)

<0.0001

1.63 (1.00, 2.66)

Hypertension

391 (25.3)

522 (45.2)

<0.0001

1.99 (1.52, 2.60)

Hypercholesterolaemia

454 (29.4)

945 (81.9)

<0.0001

10.70 (8.11, 14.11)

Ever smoked

856 (55.4)

849 (73.6)

<0.0001

1.72 (1.32, 2.25)

BMI

Mean (SD)

27.16 (4.62)

Mean (SD)

27.74 (4.05)

0.0002

1.00 (0.97, 1.04)

  1. * Univariate conditional logistic regression for binary factors and linear regression clustered by family for body mass index (BMI)
  2. † Odds ratio (OR) and 95% confidence intervals from multivariable conditional logistic regression analysis including all six factors
  3. SD: standard deviation