| Dataset (years) | |||||
---|---|---|---|---|---|---|
Immune-mediated disease (ICD code3) | ORLS1 (1963 to 1998) Rate ratio (95% CI) P-value | ORLS2 (1999 to 2008) Rate ratio (95% CI) P-value | England (1999 to 2008) Rate ratio (95% CI) P-value | |||
Addison's disease (255.4) | 1.49 (0.79 to 2.55) | 0.20 | 2.96 (1.53 to 5.20) | < 0.001 | 2.15 (1.86 to 2.47) | < 0.001 |
Ankylosing spondylitis (720) | 1.35 (0.80 to 2.13) | 0.26 | 1.18 (0.56 to 2.17) | 0.73 | 1.93 (1.74 to 2.14) | < 0.001 |
Autoimmune haemolytic anaemia (283) | 2.83 (1.62 to 4.60) | <0.001 | 3.64 (2.11 to 5.85) | <0.001 | 3.83 (3.43 to 4.25) | < 0.001 |
Chronic active hepatitis (571.4) | 2.24 (1.25 to 3.70) | 0.003 | 3.99 (1.46 to 8.72) | 0.001 | 2.04 (1.65 to 2.50) | <0.001 |
Coeliac disease (579.0) | 1.35 (0.89 to 1.97) | 0.21 | 1.36 (0.87 to 2.03) | 0.17 | 1.21 (1.11 to 1.33) | <0.001 |
Dermatomyositis, polymyositis (710.3,710.4) | 1.98 (0.99 to 3.55) | 0.04 | 2.90 (1.16 to 5.98) | 0.009 | 3.04 (2.60 to 3.54) | <0.001 |
Diabetes mellitus under 30 (250) | 2.13 (1.33 to 3.26) | 0.001 | 3.22 (1.79 to 5.54) | <0.001 | 2.58 (2.22 to 2.98) | <0.001 |
Goodpasture's syndrome (446.2) | 2.29 (0.28 to 8.28) | 0.50 | 6.89 (1.87 to 17.7) | <0.001 | 2.78 (1.78 to 4.14) | <0.001 |
Hashimoto's thyroiditis (245) | 0.89 (0.38 to 1.75) | 0.87 | 0.91 (0.19 to 2.67) | 0.91 | 1.41 (1.15 to 1.72) | 0.001 |
Idiopathic thrombocytopenia purpura (287.3) | 2.04 (0.93 to 3.88) | 0.05 | 1.58 (0.97 to 2.42) | 0.05 | 2.09 (1.90 to 2.29) | <0.001 |
Multiple sclerosis (340) | 2.24 (1.83 to 2.72) | <0.001 | 2.52 (2.00 to 3.13) | <0.001 | 2.14 (2.03 to 2.26) | <0.001 |
Myasthenia gravis (358) | 2.04 (1.09 to 3.49) | 0.02 | 2.34 (1.24 to 4.01) | 0.003 | 2.26 (2.00 to 2.54) | <0.001 |
Myxoedema (244) | 1.47 (1.27 to 1.70) | <0.001 | 1.36 (1.22 to 1.52) | <0.001 | 1.30 (1.27 to 1.33) | <0.001 |
Pemphigus, pemphigoid (694.4,694.5) | 2.69 (1.90 to 3.70) | <0.001 | 3.28 (2.07 to 4.94) | < 0.001 | 2.22 (2.00 to 2.45) | <0.001 |
Pernicious anaemia (281) | 1.20 (0.99 to 1.44) | 0.06 | 1.44 (0.97 to 2.07) | 0.06 | 1.36 (1.27 to 1.45) | <0.001 |
Polyarteritis nodosa (446) | 2.88 (1.70 to 4.55) | <0.001 | 4.36 (0.90 to 12.8) | 0.03 | 3.53 (2.76 to 4.44) | <0.001 |
Primary biliary cirrhosis (571.6) | 1.29 (0.52 to 2.67) | 0.64 | 2.76 (1.37 to 4.95) | 0.001 | 1.49 (1.26 to 1.74) | <0.001 |
Psoriasis (696.0,696.1,696.8,696.9) | 1.62 (1.32 to 1.98) | <0.001 | 1.65 (1.23 to 2.17) | <0.001 | 1.66 (1.57 to 1.75) | <0.001 |
Rheumatoid arthritis (714) | 1.45 (1.31 to 1.60) | <0.001 | 1.57 (1.37 to 1.79) | <0.001 | 1.75 (1.70 to 1.80) | <0.001 |
Scleroderma (710.1) | 2.16 (0.99 to 4.10) | 0.03 | 1.53 (0.70 to 2.91) | 0.29 | 1.97 (1.73 to 2.23) | <0.001 |
Sjogren's syndrome (710.2) | 2.85 (1.37 to 5.25) | 0.001 | 1.91 (1.02 to 3.28) | 0.03 | 2.02 (1.80 to 2.26) | <0.001 |
Systemic lupus erythematosus (710.0) | 3.61 (2.36 to 5.31) | <0.001 | 4.60 (3.19 to 6.43) | <0.001 | 3.71 (3.43 to 4.02) | <0.001 |
Thyrotoxicosis (242) | 1.14 (0.95 to 1.36) | 0.14 | 1.56 (1.23 to 1.95) | <0.001 | 1.34 (1.27 to 1.42) | <0.001 |