From: Friedreich's ataxia: the vicious circle hypothesis revisited
Organism | Increased ROS production/low glutathione | Increased peroxidation products | Hypersensitivity to oxidative insults | Loss of ISP activity | Mitochondrial iron overload | References |
---|---|---|---|---|---|---|
Saccharomyces cerevisiae yeast | +/++ | +++ | +++ | +++ | +++ | [19] |
Arabidopsis thaliana plant | + | n.d. | +++ | +++ | ++ | [69] |
Caenorhabditis elegans worm | n.d. | n.d. | +++ | +++ | n.d. | [50] |
Drosophila melanogaster fly | (+) | n.d. | +++ | +++ | n.d. | [70] |
Mus musculus mouse (humanised) | n.d. | +++ | n.d. | +++ | - | [20] |
Homo sapiens heart | n.d. | n.d. | n.d. | +++ | ++ | [4] |
Homo sapiens lymphoblasts | n.d. | - | +++ | - | - | [14] |
Homo sapiens skin fibroblasts | + | - | +++ | - | - | [9] |