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Figure 1 | BMC Medicine

Figure 1

From: Evidence for somatic gene conversion and deletion in bipolar disorder, Crohn's disease, coronary artery disease, hypertension, rheumatoid arthritis, type-1 diabetes, and type-2 diabetes

Figure 1

A model of gene conversion between duplicons. Two homologous but non-allelic sequences are shown, with homology indicated by a common green color. After a double strand break in the original sequence, the template sequence is used to form a heteroduplex DNA structure with the original sequence during the process of repair. A possible repair outcome is shown, illustrating changes to both the template and original sequences far from the location of the break, as well as changes and deletion in the original sequence in the vicinity of the break.

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BMC Medicine

ISSN: 1741-7015

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