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Table 1 Genotype and allele distributions of the six SNPs in the MUC4 gene in Taiwanese endometriosis patients and controlsa

From: MUC4gene polymorphisms associate with endometriosis development and endometriosis-related infertility

SNPs

Genotype/allele

No. (%)of patients

HWE

No. (%)of controls

HWE

Pvalue

OR (95% CI)

rs882605

TT

9

(7.0)

0.62

10

(7.2)

0.07

0.04

1.13

(0.43 to 3.00)

 

TG

54

(42.2)

 

40

(28.8)

  

1.97

(1.17 to 3.32)b

 

GG

65

(50.8)

 

89

(64.0)

  

1.00

Reference

 

T

72

(28.1)

 

60

(21.6)

 

0.08

1.42

(0.96 to 2.11)

 

G

184

(71.9)

 

218

(78.4)

  

1.00

Reference

rs1104760

CC

7

(5.4)

0.94

9

(6.3)

0.09

0.30

0.96

(0.33 to 2.82)

 

CT

47

(36.2)

 

39

(27.5)

  

1.49

(0.89 to 2.51)

 

TT

76

(58.5)

 

94

(66.2)

  

1.00

Reference

 

C

61

(23.5)

 

57

(20.1)

 

0.34

1.22

(0.81 to 1.84)

 

T

199

(76.5)

 

227

(79.9)

  

1.00

Reference

rs2246901

GG

8

(6.0)

0.96

10

(7.1)

0.15

0.56

0.91

(0.33 to 2.53)

 

TG

49

(36.6)

 

43

(30.5)

  

1.30

(0.78 to 2.17)

 

TT

77

(57.5)

 

88

(62.4)

  

1.00

reference

 

G

65

(24.3)

 

63

(22.3)

 

0.60

1.11

(0.75 to 1.65)

 

T

203

(75.7)

 

219

(77.7)

  

1.00

Reference

rs2258447

AA

9

(6.4)

0.37

10

(7.0)

0.07

0.70

1.02

(0.38 to 2.77)

 

AG

44

(32.1)

 

40

(28.2)

  

1.25

(0.74 to 2.11)

 

GG

81

(61.4)

 

92

(64.8)

  

1.00

Reference

 

A

62

(22.5)

 

60

(21.1)

 

0.57

1.12

(0.75 to 1.68)

 

G

206

(77.5)

 

224

(78.9)

  

1.00

Reference

rs2291652

CC

11

(8.7)

0.92

11

(8.4)

0.26

0.52

1.17

(0.46 to 2.96)

 

CT

52

(40.9)

 

45

(34.4)

  

1.35

(0.81 to 2.28)

 

TT

64

(50.4)

 

75

(57.3)

  

1.00

Reference

 

C

74

(29.1)

 

67

(25.6)

 

0.36

1.20

(0.81 to 1.76)

 

T

180

(70.9)

 

195

(74.4)

  

1.00

Reference

rs2688513

CC

8

(6.0)

0.62

10

(7.0)

0.09

0.66

0.91

(0.33 to 2.53)

 

TC

45

(33.8)

 

41

(28.9)

  

1.25

(0.74 to 2.10)

 

TT

80

(60.2)

 

91

(64.1)

  

1.00

Reference

 

C

61

(22.9)

 

61

(21.5)

 

0.68

1.09

(0.73 to 1.63)

 

T

205

(77.1)

 

223

(78.5)

  

1.00

Reference

  1. a MUC4, mucin 4 gene; SNP, single-nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval; HWE, P values of deviation from the Hardy-Weinberg equilibrium constant. Allelic frequencies were determined by χ2 test using 2 × 2 contingency tables. Genotype frequencies were determined by χ2 test using 2 × 3 contingency tables. b P < 0.05 was considered statistically significant.