Figure 2

Fixed-effect model meta-analysis. This figure shows the fixed-effect model meta-analysis of the six outcomes included in the meta-analyses. A) Studies for risk of grade 3 and 4 infections (as shown by the diamond at the bottom) show no evidence for increased risk in R-C vs. C arm and negligible heterogeneity (I-squared <20%). B) Three studies for risk of death as a consequence of infection; no evidence for increased risk in R-C vs. C arm and negligible heterogeneity (I-squared <20%) was found. C). Eight studies for risk of grade 3 and 4 granulocytopenia; significant evidence for increased risk in R-C vs. C was found, although moderate evidence of heterogeneity (I-squared = 20% to 50%) was present. D) Eight studies for risk of grade 3 and 4 leucopenia; significant evidence for increased risk in R-C vs. C was found, although moderate evidence of heterogeneity (I-squared = 20% to 50%) was present. E). Two studies for risk of febrile neutropenia; no evidence for increased risk in R-C vs. C arm and negligible heterogeneity (I-squared <20%) was found. F) Fourteen studies for overall response; overall response was significantly better in R-C vs. C, although strong evidence of heterogeneity (I-squared = >50%) was present. RR = risk ratio, 95% CI = 95% confidence interval.