Prescription | Low GI risk | Mod. GI risk | High GI risk | P** value | |||
---|---|---|---|---|---|---|---|
No CV Hx* | CV Hx | No CV Hx | CV Hx | No CV Hx | CV Hx | ||
N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | ||
N = 1,144 | N = 62 | N = 4,373 | N = 871 | N = 5,697 | N = 4,323 | ||
SYSADOA | 52 (4.6) | 0 (0.0) | 92 (2.1) | 22 (2.5) | 44 (0.8) | 33 (0.8) | <0.0001 |
Paracetamol | 108 (9.4) | 13 (21.0) | 391 (8.9) | 121 (13.9) | 331 (5.8) | 480 (11.1) | <0.0001 |
Opioids | 11 (1.0) | 1 (1.6) | 40 (0.9) | 11 (1.3) | 28 (0.5) | 28 (0.7) | 0.03 |
Combinations of any of the 3* | 72 (6.2) | 5 (8.0) | 306 (7.0) | 97 (11.1) | 498 (8.7) | 586 (13.5) | <0.0001 |
nsNSAIDs | 554 (48.4) | 27 (43.5) | 2,091 (47.8) | 353 (40.5) | 2,807 (49.3) | 1,789 (41.4) | <0.0001 |
nsNSAID+ GP*** | 307/554 (55.4) | 18/27 (66.7) | 1,687/2,091 (80.7) | 302/353 (85.6) | 2,552/2,807 (90.9) | 1,691/1,789 (94.5) | <0.0001 |
Cox-2 NSAID | 267 (23.3) | 13 (21.0) | 1,335 (30.5) | 227 (26.1) | 2,154 (37.8) | 1,428 (33.0) | <0.0001 |
Cox-2 + GP*** | 89/267 (33.3) | 4/13 (30.8) | 694/1,335 (52.0) | 149/227 (65.6) | 1,554/2,154 (72.1) | 1,177/1,428 (82.4) | <0.0001 |