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Table 2 Type of prescription based on GI risk and CV history

From: Prescription patterns and appropriateness of NSAID therapy according to gastrointestinal risk and cardiovascular history in patients with diagnoses of osteoarthritis

Prescription

Low GI risk

Mod. GI risk

High GI risk

P** value

 

No CV Hx*

CV Hx

No CV Hx

CV Hx

No CV Hx

CV Hx

 
 

N (%)

N (%)

N (%)

N (%)

N (%)

N (%)

 
 

N = 1,144

N = 62

N = 4,373

N = 871

N = 5,697

N = 4,323

 

SYSADOA

52 (4.6)

0 (0.0)

92 (2.1)

22 (2.5)

44 (0.8)

33 (0.8)

<0.0001

Paracetamol

108 (9.4)

13 (21.0)

391 (8.9)

121 (13.9)

331 (5.8)

480 (11.1)

<0.0001

Opioids

11 (1.0)

1 (1.6)

40 (0.9)

11 (1.3)

28 (0.5)

28 (0.7)

0.03

Combinations of any of the 3*

72 (6.2)

5 (8.0)

306 (7.0)

97 (11.1)

498 (8.7)

586 (13.5)

<0.0001

nsNSAIDs

554 (48.4)

27 (43.5)

2,091 (47.8)

353 (40.5)

2,807 (49.3)

1,789 (41.4)

<0.0001

nsNSAID+ GP***

307/554 (55.4)

18/27 (66.7)

1,687/2,091 (80.7)

302/353 (85.6)

2,552/2,807 (90.9)

1,691/1,789 (94.5)

<0.0001

Cox-2 NSAID

267 (23.3)

13 (21.0)

1,335 (30.5)

227 (26.1)

2,154 (37.8)

1,428 (33.0)

<0.0001

Cox-2 + GP***

89/267 (33.3)

4/13 (30.8)

694/1,335 (52.0)

149/227 (65.6)

1,554/2,154 (72.1)

1,177/1,428 (82.4)

<0.0001

  1. CV HX = cardiovascular history; GP = gastroprotectant (>91% PPI).
  2. * Sysadoa, paracetamol, opioids; ** P-values denotes differences among groups overall; *** nsNSAIDS + GP data express the number of patients and % of patients with nsNSAIDs prescription that also take a gastroprotective agent. Also, COX-2 + GP data express the number of patients and % of patients with COX-2 selective inhibitors prescriptions that also take a gastroprotective agent.