Outcome measure | Baseline | Post L-lysine | Post placebo | F value | P-value* |
---|---|---|---|---|---|
L-lysine blood conc (μmol/l) | 196 ± 14 (201 ± 15) | 401 ± 74 (363 ± 64) | 195 ± 13 (195 ± 10) | 7.84 (6.57) | 0.024 (0.027) |
Symptom severity scales | |||||
PANSS | |||||
Positive symptoms | 14.6 ± 0.7 (16.0 ± 1.1) | 11.9 ± 0.6 (13.5 ± 1.3) | 11.6 ± 0.8 (13.4 ± 1.4) | 13.11 (12.49) | 0.001 (0.000) |
Negative symptoms | 18.4 ± 2.4 (19.7 ± 2.2) | 17.4 ± 2.2 (19.4 ± 2.2) | 17.3 ± 2.4 (18.8 ± 2.2) | 1.53 (0.69) | 0.25 (0.51) |
General symptoms | 31.3 ± 2.5 (33.5 ± 2.5) | 29.5 ± 1.9 (32.3 ± 2.4) | 29.1 ± 2.0 (30.9 ± 2.0) | 2.14 (2.84) | 0.16 (0.09) |
Total | 64.3 ± 4.2 (69.2 ± 4.7) | 58.8 ± 4.0 (65.2 ± 5.4) | 58.0 ± 4.5 (63.1 ± 5.0) | 13.36 (8.59) | 0.001 (0.002) |
GAF | 43.8 ± 1.8 (42.0 ± 1.9) | 46.9 ± 1.6 (45.8 ± 1.6) | 44.1 ± 2.3 (42.8 ± 2.1) | 4.29 (7.34) | 0.035 (0.005) |
CGI | 3.63 ± 0.18 (3.80 ± 0.20) | 3.63 ± 0.18 (3.80 ± 0.20) | 3.50 ± 0.27 (3.70 ± 0.26) | 1.00 (1.00) | 0.39 (0.39) |
Depression scale | |||||
MADRS | 8.50 ± 2.09 (9.10 ± 1.74) | 7.50 ± 1.90 (7.90 ± 1.57) | 8.38 ± 1.74 (8.40 ± 1.38) | 0.54 (0.89) | 0.59 (0.43) |
Cognitive tests | |||||
RAVLT | 45.9 ± 4.3 (43.5 ± 4.2) | 46.0 ± 4.6 (43.3 ± 4.4) | 48.8 ± 3.5 (45.2 ± 4.1) | 0.79 (0.48) | 0.47 (0.62) |
CPT | 0.76 ± 0.16 (0.67 ± 0.13) | 0.81 ± 0.13 (0.76 ± 0.12) | 0.86 ± 0.13 (0.71 ± 0.14) | 0.25 (0.21) | 0.77 (0.81) |
Trail Making Test A | 33.8 ± 1.7 (39.2 ± 5.9) | 31.3 ± 2.5 (39.9 ± 8.9) | 35.3 ± 4.5 (40.8 ± 6.3) | 0.44 (0.07) | 0.58 (0.93) |
Trail Making Test B | 77.4 ± 7.2 (134 ± 56) | 70.0 ± 5.2 (119 ± 48) | 71.3 ± 6.4 (124 ± 50) | 0.40 (1.61) | 0.68 (0.24) |
Letter and number span | 8.13 ± 0.90 (7.00 ± 1.03) | 9.00 ± 0.66 (8.10 ± 0.82) | 9.13 ± 0.92 (8.50 ± 0.95) | 0.74 (1.92) | 0.50 (0.18) |
Wisconsin Card Sorting | |||||
Number of errors | 33.9 ± 10.0 (31.9 ± 9.0) | 21.0 ± 7.2 (19.7 ± 6.5) | 24.4 ± 10.1 (23.2 ± 9.0) | 4.91 (5.45) | 0.024 (0.016) |
Perseverant errors | 20.4 ± 7.6 (19.0 ± 6.8) | 11.5 ± 5.0 (10.7 ± 4.4) | 14.8 ± 8.1 (13.4 ± 7.3) | 4.46 (5.00) | 0.032 (0.021) |
Perseverant answers | 23.6 ± 9.6 (21.9 ± 8.7) | 13.1 ± 6.6 (21.1 ± 5.9) | 17.1 ± 10.3 (15.6 ± 9.2) | 4.77 (5.20) | 0.026 (0.018) |