From: FTO gene polymorphisms and obesity risk: a meta-analysis
Study | N (case/control) | OR [95% CI], P-value | ||||||
---|---|---|---|---|---|---|---|---|
 | Subtotal | MAF | PHWE | 11a | 12 | 22 | Additive model | Allelic comparison |
rs9939609 | ||||||||
Caucasian: | Â | Â | Â | Â | Â | Â | Â | Â |
Frayling_a | 5,380 (353/5,027) | 0.48/0.39 | 0.513 | 107/1,879 | 157/2,407 | 89/741 | 1.43 (1.23 to 1.67) | 1.43 (1.23 to 1.67) |
Frayling_b | 3,072 (415/2,657) | 0.45/0.37 | 0.185 | 132/1,060 | 193/1,211 | 90/386 | 1.36 (1.18 to 1.57) | 1.37 (1.18 to 1.59) |
Frayling_c | 487 (126/361) | 0.42/0.38 | 0.575 | 45/138 | 56/175 | 25/48 | 1.21 (0.90 to 1.62) | 1.21 (0.91 to 1.61) |
Frayling_d | 623 (200/423) | 0.41/0.34 | 0.447 | 67/189 | 101/182 | 32/52 | 1.37 (1.07 to 1.75) | 1.37 (1.08 to 1.76) |
Frayling_e | 2,511 (1,588/923) | 0.43/0.38 | 0.625 | 485/351 | 847/443 | 256/129 | 1.24 (1.10 to 1.40) | 1.22 (1.09 to 1.37) |
Frayling_f | 1,875 (840/1,035) | 0.42/0.37 | 0.547 | 274/421 | 427/471 | 139/143 | 1.26 (1.10 to 1.44) | 1.25 (1.10 to 1.43) |
Frayling_g | 461 (212/249) | 0.47/0.42 | 0.514 | 66/82 | 92/127 | 54/40 | 1.25 (0.97 to 1.61) | 1.26 (0.97 to 1.63) |
Andreasen_a | 3,724 (1,045/2,679) | 0.45/0.39 | 0.103 | 313/993 | 517/1,309 | 215/377 | 1.33 (1.20 to 1.48) | 1.32 (1.19 to 1.47) |
Andreasen_b | 4,671 (2,819/1,852) | 0.43/0.39 | 0.221 | 911/684 | 1,385/904 | 523/264 | 1.21 (1.11 to 1.31) | 1.20 (1.11 to 1.31) |
Andreasen_c | 377 (104/273) | 0.45/0.39 | 0.076 | 30/93 | 55/145 | 19/35 | 1.27(0.91 to 1.80) | 1.25 (0.90 to 1.72) |
Muler | 697 (519/178) | 0.50/0.44 | 0.763 | 140/56 | 238/86 | 141/36 | 1.24 (0.98 to 1.57) | 1.26 (0.99 to 1.60) |
Price | 1,047 (527/520) | 0.48/0.36 | 0.084 | 152/207 | 242/257 | 133/56 | 1.69 (1.41 to 2.02) | 1.69 (1.42 to 2.02) |
Peeters | 1,367 (1,099/268) | 0.46/0.40 | 0.703 | 316/94 | 553/133 | 230/41 | 1.28 (1.05 to 1.56) | 1.28 (1.05 to 1.55) |
Jacobsson_2008 | 960 (450/510) | 0.48/0.42 | 0.716 | 133/174 | 206/244 | 111/92 | 1.24 (1.04 to 1.48) | 1.25 (1.05 to 1.50) |
Legry | 3,367 (598/2,769) | 0.46/0.41 | 0.050 | 171/924 | 307/1,395 | 120/450 | 1.20 (1.05 to 1.36) | 1.19 (1.05 to 1.35) |
Jacobsson_2009 | 1,115 (54/1,061) | 0.44/0.39 | 0.218 | 16/411 | 29/483 | 9/167 | 1.22 (0.83 to 1.80) | 1.23 (0.83 to 1.82) |
Hinney | 926 (484/442) | 0.50/0.39 | 0.690 | 123/164 | 241/214 | 120/64 | 1.57 (1.30 to 1.90) | 1.57 (1.30 to 1.88) |
Asian: | Â | Â | Â | Â | Â | Â | Â | Â |
Song_AP | 240 (77/163) | 0.20/0.17 | 0.409 | 50/114 | 23/43 | 4/6 | 1.23 (0.76 to 1.97) | 1.24 (0.76 to 2.03) |
Chang | 2,135 (610/1,525) | 0.17/0.13 | 0.355 | 425/1,158 | 167/347 | 18/20 | 1.38 (1.15 to 1.66) | 1.37 (1.14 to 1.5) |
Hotta | 2,423 (919/1,504) | 0.24/0.19 | 0.393 | 534/1,005 | 334/443 | 51/56 | 1.37 (1.19 to 1.58) | 1.66 (1.31 to 2.11) |
Tabara | 1,718 (214/1,504) | 0.22/0.16 | 0.438 | 128/1,063 | 77/408 | 9/33 | 1.54 (1.20 to 1.99) | 1.53 (1.19 to 1.95) |
Karasawa | 2,639 (794/1,845) | 0.23/0.20 | 0.373 | 477/1,203 | 271/566 | 46/76 | 1.22 (1.06 to 1.41) | 1.23 (1.06 to 1.42) |
Liu | 1,167 (276/891) | 0.14/0.11 | 0.396 | 201/701 | 70/181 | 5/8 | 1.38 (1.04 to 1.83) | 1.36 (1.03 to 1.80) |
Li | 3,210 (398/2,812) | NA/0.12 | NA | NA | NA | NA | 0.90 (0.70 to 1.15) | NA |
Hispanic: | Â | Â | Â | Â | Â | Â | Â | Â |
Song_H | 415 (139/276) | 0.27/0.31 | 0.157 | 75/138 | 53/107 | 11/31 | 0.85 (0.62 to 1.16) | 0.84 (0.61 to 1.15 |
Gonzalez | 725 (207/518) | 0.45/0.37 | 0.925 | 62/203 | 104/244 | 41/71 | 1.38 (1.09 to 1.74) | 1.37 (1.09 to 1.73) |
Zabena | 255 (75/180) | 0.52/0.34 | 1.0 | 19/78 | 34/81 | 22/21 | 2.04 (1.38 to 3.02) | 2.09 (1.42 to 3.07) |
African: | Â | Â | Â | Â | Â | Â | Â | Â |
Song_B | 1,114 (365/749) | 0.47/0.45 | 0.160 | 113/239 | 161/351 | 91/159 | 1.09 (0.92 to 1.30) | 1.10 (0.92 to 1.31) |
South American: | Â | Â | Â | Â | Â | Â | Â | Â |
Villalobos | 788 (364/424) | 0.25/0.17 | 0.598 | 209/297 | 127/114 | 28/13 | 1.66 (1.31 to 2.11) | 1.7 (1.33 to 2.17) |
Mixed: | Â | Â | Â | Â | Â | Â | Â | Â |
Willer | 19,367 (5,261/14,106) | NA | NA | NA | NA | NA | NA | 1.25 (1.19 to 1.31) |
Total N (rs9939609) | 68,856 (21,132/47,724) | Â | Â | Â | Â | Pooled ORs | 1.31 (1.25 to 1.37) | 1.31 (1.26 to 1.36) |
rs1421085 | ||||||||
Causian: | Â | Â | Â | Â | Â | Â | Â | Â |
Dina_a | 3,557 (867/2,690) | 0.52/0.41 | 0.218 | 200/944 | 425/1,273 | 242/473 | 1.55 (1.39 to 1.73) | 1.57 (1.41 to 1.75) |
Dina_b | 1,678 (699/979) | 0.51/0.42 | 0.896 | 173/323 | 334/481 | 192/175 | 1.42 (1.24 to 1.63) | 1.43 (1.25 to 1.64) |
Dina_c | 1,001 (482/519) | 0.51/0.41 | 0.205 | 119/187 | 233/237 | 130/95 | 1.47 (1.24 to 1.75) | 1.50 (1.26 to 1.79) |
Dina_d | 1,018 (504/514) | 0.52/0.46 | 0.051 | 123/161 | 235/233 | 146/120 | 1.26 (1.07 to 1.49) | 1.29 (1.08 to 1.53) |
Dina_e | 551 (283/268) | 0.53/0.40 | 0.637 | 62/246 | 142/343 | 79/110 | 1.69 (1.38 to 2.06) | 1.67 (1.37 to 2.04) |
Peeters | 1,367 (1,099/268) | 0.48/0.41 | 0.900 | 300/93 | 544/129 | 255/46 | 1.31 (1.08 to 1.59) | 1.31 (1.09 to 1.59) |
Attaoua | 248 (119/129) | 0.55/0.41 | 0.585 | 24/47 | 58/59 | 37/23 | 1.78 (1.24 to 2.54) | 1.81 (1.27 to 2.59) |
Meyre_FC | 1,036 (491/545) | 0.49/0.41 | 0.077 | 137/197 | 231/244 | 123/104 | 1.31 (1.11 to 1.55) | 1.33 (1.12 to 1.59) |
Meyre_FA | 859 (132/727) | 0.51/0.43 | 0.820 | 31/238 | 67/359 | 34/130 | 1.42 (1.09 to 1.85) | 1.41 (1.09 to 1.84) |
Meyre_SA | 1,346 (1,028/318) | 0.50/0.46 | 0.055 | 286/100 | 460/141 | 282/77 | 1.13 (0.96 to 1.34) | 1.15 (0.96 to 1.37) |
Meyre_GC | 1,080 (370/710) | 0.55/0.45 | 0.081 | 76/227 | 181/328 | 113/155 | 1.47 (1.23 to 1.75) | 1.50 (1.25 to 1.79) |
Total N (rs1421085) | 13,741 (6,074/7,667) | Â | Â | Â | Â | Pooled ORs | 1.41 (1.31 to 1.51) | 1.43 (1.33 to 1.53) |
rs8050136 | ||||||||
Caucasian: | Â | Â | Â | Â | Â | Â | Â | Â |
Hinney | 928 (486/442) | 0.50/0.39 | 0.842 | 123/165 | 240/212 | 123/65 | 1.58 (1.31 to 1.91) | 1.59 (1.32 to 1.91) |
Grant_C | 2,688 (418/2,270) | 0.45/0.39 | NA | NA | NA | NA | NA | 1.27 (1.09 to 1.47) |
Asian: | Â | Â | Â | Â | Â | Â | Â | Â |
Song_AP | 240 (77/163) | 0.20/0.18 | 0.425 | 52/111 | 20/45 | 5/7 | 1.09 (0.68 to 1.73) | 1.10 (0.67 to 1.78) |
Cheung | 1,159 (468/691) | 0.16/0.12 | 0.463 | 326/535 | 131/149 | 11/7 | 1.48 (1.16 to 1.89) | 1.46 (1.15 to 1.85) |
Liu | 1,180 (278/902) | 0.15/0.11 | 0.489 | 201/716 | 73/178 | 4/8 | 1.43 (1.08 to 1.91) | 1.42 (1.07 to 1.87) |
Li | 3,210 (398/2,812) | NA/0.12 | NA | NA | NA | NA | 0.91 (0.71 to 1.16) | NA |
African: | Â | Â | Â | Â | Â | Â | Â | Â |
Song_B | 1,114 (365/749) | 0.42/0.42 | 0.454 | 133/257 | 161/355 | 71/137 | 0.98 (0.82 to 1.17) | 0.98 (0.82 to 1.17) |
Grant_AA | 2,002 (578/1,424) | 0.45/0.44 | NA | NA | NA | NA | NA | 1.05 (0.91 to 1.21) |
Mixed: | Â | Â | Â | Â | Â | Â | Â | Â |
Thorleifsson | 22,277 (13,785/8,492) | NA | NA | NA | NA | NA | NA | 1.27 (1.21 to 1.32) |
Total N (rs8050136) | 34,798 (16,853/17,945) | Â | Â | Â | Â | Pooled ORs | 1.22 (0.99 to 1.51) | 1.25 (1.13 to 1.38) |
rs17817449 | ||||||||
Caucasian: | Â | Â | Â | Â | Â | Â | Â | Â |
Dina_a [6] | 3,548 (873/2,675) | 0.49/0.60 | 0.968 | 212/948 | 426/1,288 | 235/439 | 1.55 (1.39 to 1.72) | 1.55 (1.39 to 1.73) |
Dina_b | 1,589 (689/900) | 0.47/0.59 | 0.600 | 164/337 | 320/489 | 205/164 | 1.59 (1.38 to 1.83) | 1.60 (1.40 to 1.84) |
Dina_c | 1,010 (485/525) | 0.49/0.60 | 0.173 | 120/196 | 236/237 | 129/92 | 1.52 (1.28 to 1.81) | 1.55 (1.30 to 1.85) |
Dina_d | 1,035 (516/519) | 0.50/0.55 | 0.374 | 138/164 | 243/246 | 135/109 | 1.21 (1.02 to 1.43) | 1.22 (1.03 to 1.45) |
Dina_e | 972 (281/691) | 0.46/0.58 | 0.755 | 58/231 | 142/341 | 81/119 | 1.65 (1.35 to 2.01) | 1.63 (1.34 to 1.99) |
Price | 1,049 (527/522) | 0.49/0.36 | 0.087 | 145/205 | 247/259 | 135/58 | 1.72 (1.44 to 2.06) | 1.72 (1.44 to 2.05) |
Total N (rs17817449) | 9,203 (3,371/5,832) | Â | Â | Â | Â | Pooled ORs | 1.53 (1.40 to 1.67) | 1.54 (1.41 to 1.68) |
rs1121980 | ||||||||
Caucasian: | Â | Â | Â | Â | Â | Â | Â | Â |
Hinney | 926 (484/442) | 0.53/0.41 | 0.694 | 104/153 | 247/218 | 133/71 | 1.66 (1.37 to 2.01) | 1.64 (1.37 to 1.97) |
Renstrom | 1,723 (353/1,370) | NA | NA | NA | NA | NA | NA | 1.15 (1.05 to 1.25) |
Asian: | Â | Â | Â | Â | Â | Â | Â | Â |
Hotta | 2,451 (927/1,524) | 0.26/0.21 | 0.593 | 499/947 | 367/504 | 61/73 | 1.32 (1.15 to 1.51) | 1.32 (1.16 to 1.51) |
Total N (rs1121980) | 5,100 (1,764/3,336) | Â | Â | Â | Â | Pooled ORs | 1.46 (1.17 to 1.83) | 1.34 (1.10 to 1.62) |
Total Subjects (duplicated subjects were excluded) | 112,327 (42,616/69,711) |