From: Evidence-based guidelines for use of probiotics in preterm neonates
Specific recommendations | LOEa[reference] | |
---|---|---|
Selection of strains | Combination containing Lactobacillus and at least one Bifidobacterium species is preferable. Lactobacillus GG alone may not be effective | |
Dose | 3 × 109 organisms per day, preferably in a single dose | |
When to start? | When the neonate is ready for enteral feeds, preferably within first 7 days of life | |
How long to continue? | At least until 35 weeks corrected age, or discharge | |
Supplementation during acute illness | Stopping the supplementation during an acute illness such as sepsis, NECbor perinatal asphyxia may be safe |