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Table 1 Response rates in phase 3 studies comparing imatinib with nilotinib or dasatinib

From: Advances in the treatment of chronic myeloid leukemia

 

DASISION

ENESTnd

Median follow-up (months)

18

NR

Minimum follow-up (months)

16

24

 

Dasatinib 100 mg QD

Imatinib 400 mg QD

Nilotinib 300 mg BID

Nilotinib 400 mg BID

Imatinib 400 mg QD

 

(N = 259)

(N = 260)

(N = 282)

(N = 281)

(N = 283)

Confirmed complete cytogenetic response by 18 mo (%)

78

70

NR

NR

NR

Major molecular response at any time (%)

57

41

71

67

44

Complete molecular response at any time (%)

13

7

26

21

10

Overall survival (%)

96.0

97.9

97.4

97.8

96.4

Progression-free survival (%)

94.9

93.7

98

97.7

95.2

Discontinued treatment (%)

19

20

26

22

33

  1. Data are based on the update reported at the 2010 Annual Meeting of the American Society of Hematology in Orlando, FL. NR = not reported